FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916619782> ?p ?o ?g. }

• W2916619782 endingPage "17279" @default.
• W2916619782 startingPage "17269" @default.
• W2916619782 abstract "Abstract Long noncoding RNAs have been reported to play important roles in the pathogenesis of diabetic retinopathy (DR), which has been considered as the most common disease leading to vision loss. However, it is still unclear whether KCNQ1 overlapping transcript 1 (KCNQ1OT1) could affect DR. In this study, regarding quantitative reverse transcription polymerase chain reaction assay, KCNQ1OT1 level was upregulated while microRNA‐1470 (miR‐1470) was decreased in DR patients and human retinal endothelial cells. High KCNQ1OT1 expression was correlated with DR stage and low visual function. Using miR‐1470 mimic or knockdown of KCNQ1OT1 could lead to the similar phenomenon; phospho‐AKT, Bax, B‐cell lymphoma 2, and cleaved poly‐ADP ribose polymerase (PARP) were regulated, while vascularization was inhibited and apoptosis was promoted. Regarding bioinformatics analysis and in vitro dual luciferase reporter assay, there should be a negative correlation between KCNQ1OT1 and miR‐1470. Additionally, mRNA of epidermal growth factor receptor (EGFR) was proved as the target of miR‐1470 and EGFR targeting by miR‐1470 initiated KCNQ1OT1 deficiency‐induced apoptosis and promoted proliferation. KCNQ1OT1 and miR‐1470 were proved to be the promoter and repressor of EGFR, respectively. The results suggested that KCNQ1OT1 could sponge miR‐1470 and further regulate EGFR in DR." @default.
• W2916619782 created "2019-03-02" @default.
• W2916619782 creator A5007946638 @default.
• W2916619782 creator A5014669578 @default.
• W2916619782 creator A5019712754 @default.
• W2916619782 creator A5033394512 @default.
• W2916619782 creator A5037954064 @default.
• W2916619782 creator A5045452450 @default.
• W2916619782 creator A5047193639 @default.
• W2916619782 creator A5068706085 @default.
• W2916619782 date "2019-02-19" @default.
• W2916619782 modified "2023-10-17" @default.
• W2916619782 title "KCNQ1OT1 affects the progression of diabetic retinopathy by regulating miR‐1470 and epidermal growth factor receptor" @default.
• W2916619782 cites W123990481 @default.
• W2916619782 cites W1965422765 @default.
• W2916619782 cites W1984244571 @default.
• W2916619782 cites W2015020480 @default.
• W2916619782 cites W2061705235 @default.
• W2916619782 cites W2076873046 @default.
• W2916619782 cites W2151473756 @default.
• W2916619782 cites W2267388772 @default.
• W2916619782 cites W2317958404 @default.
• W2916619782 cites W2341291028 @default.
• W2916619782 cites W2404312699 @default.
• W2916619782 cites W2412207461 @default.
• W2916619782 cites W2502770791 @default.
• W2916619782 cites W2565213206 @default.
• W2916619782 cites W2581363352 @default.
• W2916619782 cites W2590312224 @default.
• W2916619782 cites W2602185627 @default.
• W2916619782 cites W2605314119 @default.
• W2916619782 cites W2617909456 @default.
• W2916619782 cites W2724309747 @default.
• W2916619782 cites W2736434822 @default.
• W2916619782 cites W2741396406 @default.
• W2916619782 cites W2762335371 @default.
• W2916619782 cites W2765457786 @default.
• W2916619782 cites W2800512087 @default.
• W2916619782 cites W2803249602 @default.
• W2916619782 cites W2890037152 @default.
• W2916619782 cites W2902482674 @default.
• W2916619782 cites W2908457616 @default.
• W2916619782 doi "https://doi.org/10.1002/jcp.28344" @default.
• W2916619782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30784065" @default.
• W2916619782 hasPublicationYear "2019" @default.
• W2916619782 type Work @default.
• W2916619782 sameAs 2916619782 @default.
• W2916619782 citedByCount "24" @default.
• W2916619782 countsByYear W29166197822019 @default.
• W2916619782 countsByYear W29166197822020 @default.
• W2916619782 countsByYear W29166197822021 @default.
• W2916619782 countsByYear W29166197822022 @default.
• W2916619782 countsByYear W29166197822023 @default.
• W2916619782 crossrefType "journal-article" @default.
• W2916619782 hasAuthorship W2916619782A5007946638 @default.
• W2916619782 hasAuthorship W2916619782A5014669578 @default.
• W2916619782 hasAuthorship W2916619782A5019712754 @default.
• W2916619782 hasAuthorship W2916619782A5033394512 @default.
• W2916619782 hasAuthorship W2916619782A5037954064 @default.
• W2916619782 hasAuthorship W2916619782A5045452450 @default.
• W2916619782 hasAuthorship W2916619782A5047193639 @default.
• W2916619782 hasAuthorship W2916619782A5068706085 @default.
• W2916619782 hasConcept C104317684 @default.
• W2916619782 hasConcept C127561419 @default.
• W2916619782 hasConcept C145059251 @default.
• W2916619782 hasConcept C153911025 @default.
• W2916619782 hasConcept C170493617 @default.
• W2916619782 hasConcept C173396325 @default.
• W2916619782 hasConcept C190283241 @default.
• W2916619782 hasConcept C2779438470 @default.
• W2916619782 hasConcept C502942594 @default.
• W2916619782 hasConcept C54355233 @default.
• W2916619782 hasConcept C86803240 @default.
• W2916619782 hasConceptScore W2916619782C104317684 @default.
• W2916619782 hasConceptScore W2916619782C127561419 @default.
• W2916619782 hasConceptScore W2916619782C145059251 @default.
• W2916619782 hasConceptScore W2916619782C153911025 @default.
• W2916619782 hasConceptScore W2916619782C170493617 @default.
• W2916619782 hasConceptScore W2916619782C173396325 @default.
• W2916619782 hasConceptScore W2916619782C190283241 @default.
• W2916619782 hasConceptScore W2916619782C2779438470 @default.
• W2916619782 hasConceptScore W2916619782C502942594 @default.
• W2916619782 hasConceptScore W2916619782C54355233 @default.
• W2916619782 hasConceptScore W2916619782C86803240 @default.
• W2916619782 hasFunder F4320322769 @default.
• W2916619782 hasIssue "10" @default.
• W2916619782 hasLocation W29166197821 @default.
• W2916619782 hasOpenAccess W2916619782 @default.
• W2916619782 hasPrimaryLocation W29166197821 @default.
• W2916619782 hasRelatedWork W2024344351 @default.
• W2916619782 hasRelatedWork W2346343701 @default.
• W2916619782 hasRelatedWork W2494327966 @default.
• W2916619782 hasRelatedWork W2573992804 @default.
• W2916619782 hasRelatedWork W3204273758 @default.
• W2916619782 hasRelatedWork W3215845635 @default.
• W2916619782 hasRelatedWork W4220866825 @default.
• W2916619782 hasRelatedWork W4281477203 @default.
• W2916619782 hasRelatedWork W4281778281 @default.

• next