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• W2916643775 abstract "Urokinase plasminogen activator receptor (uPAR), a member of the lymphocyte antigen 6 protein superfamily, is overexpressed in different types of cancers and plays an important role in tumorigenesis and development. In this study, we successfully targeted uPAR by CRISPR/Cas9 system in two human cancer cell lines with two individual sgRNAs. Knockout of uPAR inhibited cell proliferation, migration and invasion. Furthermore, knockout of uPAR decreases resistance to 5-FU, cisplatin, docetaxel and doxorubicin in these cells. Although there are several limitations in the application of CRISPR/Cas9 system for cancer patients, our study offers valuable evidences for the role of uPAR in cancer malignancy and drug resistance." @default.
• W2916643775 created "2019-03-02" @default.
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• W2916643775 date "2019-02-27" @default.
• W2916643775 modified "2023-10-16" @default.
• W2916643775 title "Targeting uPAR by CRISPR/Cas9 System Attenuates Cancer Malignancy and Multidrug Resistance" @default.
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• W2916643775 doi "https://doi.org/10.3389/fonc.2019.00080" @default.
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