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- W2916662503 abstract "Biocompatible fluorescent active and pH sensitive gel has been developed using covalently attached riboflavin as proficient fluorophore on crosslinked glycogen. The chemically crosslinked glycogen (cl-Gly/PMAc) has been synthesised by grafting of methacrylic acid (MAc) followed by crosslinking using ethylene glycol dimethacrylate (EGDMA) through free radical polymerization. Afterward, the fluorescent active hydrogel (cl-Gly/PMAc-RB) has been synthesised by post-polymerization modification of cl-Gly/PMAc with riboflavin. The gel properties have been explored by determining rheological parameters. pH responsive swelling and reversible swelling behaviours of cl-Gly/PMAc-RB have been investigated by executing swelling/deswelling/reswelling studies. In-vitro cell cytotoxicity study predicts that the material is non-toxic and biocompatible. cl-Gly/PMAc-RB gel demonstrates excellent release profile towards the release of dual drugs (metronidazole: release ∼ 75% after 24 h and ciprofloxacin: release ∼ 55% after 24 h) in colonic region, which is evidenced from in vitro and in-vivo studies. Finally, ab-initio molecular dynamics study has been carried out to investigate the intricate details of the probable drugs-hydrogel interaction and pH responsive release profile of dual drugs from cl-Gly/PMAc-RB hydrogel in molecular level." @default.
- W2916662503 created "2019-03-02" @default.
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- W2916662503 date "2019-05-01" @default.
- W2916662503 modified "2023-09-25" @default.
- W2916662503 title "Biopolymeric pH-responsive fluorescent gel for in-vitro and in-vivo colon specific delivery of metronidazole and ciprofloxacin" @default.
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- W2916662503 doi "https://doi.org/10.1016/j.eurpolymj.2019.02.037" @default.
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