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- W2916699108 abstract "Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is the primary glucocorticoid in humans. Synthetic glucocorticoids are important pharmacological agents that augment the anti-inflammatory and immunosuppressive properties of endogenous cortisol and are widely used for the treatment of asthma, Crohn's disease, and rheumatoid arthritis, amongst other chronic conditions. The homeostatic activity of cortisol is disrupted by the administration of synthetic glucocorticoids and so there is interest in developing treatment options that minimize HPA axis disturbance while maintaining the pharmacological effects. Studies suggest that optimizing drug administration time can achieve this goal. The present review provides an overview of endogenous glucocorticoid activity and recent advances in treatment options that have further improved patient safety and efficacy with an emphasis on chronopharmacology." @default.
- W2916699108 created "2019-03-02" @default.
- W2916699108 creator A5028648103 @default.
- W2916699108 creator A5049184270 @default.
- W2916699108 creator A5079307634 @default.
- W2916699108 date "2019-11-01" @default.
- W2916699108 modified "2023-10-12" @default.
- W2916699108 title "Chronopharmacology of glucocorticoids" @default.
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