Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916743695> ?p ?o ?g. }
- W2916743695 endingPage "384" @default.
- W2916743695 startingPage "371" @default.
- W2916743695 abstract "Ten years ago, high-throughput genetic interaction analyses revealed an abundant and widely conserved protein complex residing in the endoplasmic reticulum (ER) membrane. Dubbed the ER membrane protein complex (EMC), its disruption has since been found to affect wide-ranging processes, including protein trafficking, organelle communication, ER stress, viral maturation, lipid homeostasis, and others. However, its molecular function has remained enigmatic. Recent studies suggest a role for EMC during membrane protein biogenesis. Biochemical reconstitution experiments show that EMC can directly mediate the insertion of transmembrane domains (TMDs) into the lipid bilayer. Given the large proportion of genes encoding membrane proteins, a central role for EMC as a TMD insertion factor can explain its high abundance, wide conservation, and pleiotropic phenotypes." @default.
- W2916743695 created "2019-03-02" @default.
- W2916743695 creator A5007776918 @default.
- W2916743695 creator A5087214606 @default.
- W2916743695 date "2019-05-01" @default.
- W2916743695 modified "2023-10-18" @default.
- W2916743695 title "The Role of EMC during Membrane Protein Biogenesis" @default.
- W2916743695 cites W1526070136 @default.
- W2916743695 cites W1722722895 @default.
- W2916743695 cites W1963682547 @default.
- W2916743695 cites W1966236299 @default.
- W2916743695 cites W1968604972 @default.
- W2916743695 cites W1972125463 @default.
- W2916743695 cites W1972399884 @default.
- W2916743695 cites W1980862780 @default.
- W2916743695 cites W1980910728 @default.
- W2916743695 cites W1982757612 @default.
- W2916743695 cites W1986206637 @default.
- W2916743695 cites W2000456126 @default.
- W2916743695 cites W2000729091 @default.
- W2916743695 cites W2004062537 @default.
- W2916743695 cites W2006135655 @default.
- W2916743695 cites W2006682862 @default.
- W2916743695 cites W2013947447 @default.
- W2916743695 cites W2015538142 @default.
- W2916743695 cites W2016266703 @default.
- W2916743695 cites W2018462246 @default.
- W2916743695 cites W2028775235 @default.
- W2916743695 cites W2035944529 @default.
- W2916743695 cites W2042688172 @default.
- W2916743695 cites W2045032671 @default.
- W2916743695 cites W2045837772 @default.
- W2916743695 cites W2053673239 @default.
- W2916743695 cites W2055654995 @default.
- W2916743695 cites W2060455308 @default.
- W2916743695 cites W2064254630 @default.
- W2916743695 cites W2069155406 @default.
- W2916743695 cites W2072220895 @default.
- W2916743695 cites W2073231769 @default.
- W2916743695 cites W2075970782 @default.
- W2916743695 cites W2076100752 @default.
- W2916743695 cites W2078326109 @default.
- W2916743695 cites W2080820963 @default.
- W2916743695 cites W2083116560 @default.
- W2916743695 cites W2102449913 @default.
- W2916743695 cites W2103356759 @default.
- W2916743695 cites W2103376319 @default.
- W2916743695 cites W2106728955 @default.
- W2916743695 cites W2109683193 @default.
- W2916743695 cites W2118016880 @default.
- W2916743695 cites W2118886634 @default.
- W2916743695 cites W2119133319 @default.
- W2916743695 cites W2120966507 @default.
- W2916743695 cites W2123235879 @default.
- W2916743695 cites W2125278050 @default.
- W2916743695 cites W2133132610 @default.
- W2916743695 cites W2133992568 @default.
- W2916743695 cites W2135593976 @default.
- W2916743695 cites W2137032962 @default.
- W2916743695 cites W2138563074 @default.
- W2916743695 cites W2140363734 @default.
- W2916743695 cites W2159519572 @default.
- W2916743695 cites W2160877102 @default.
- W2916743695 cites W2167459724 @default.
- W2916743695 cites W2168441478 @default.
- W2916743695 cites W2169755861 @default.
- W2916743695 cites W2236320371 @default.
- W2916743695 cites W2256016639 @default.
- W2916743695 cites W2290928843 @default.
- W2916743695 cites W2295631621 @default.
- W2916743695 cites W2404800615 @default.
- W2916743695 cites W2426204902 @default.
- W2916743695 cites W2439020788 @default.
- W2916743695 cites W2464834014 @default.
- W2916743695 cites W2502120512 @default.
- W2916743695 cites W2513443250 @default.
- W2916743695 cites W2566138179 @default.
- W2916743695 cites W2575766838 @default.
- W2916743695 cites W2591222538 @default.
- W2916743695 cites W2611366899 @default.
- W2916743695 cites W2616854243 @default.
- W2916743695 cites W2734566532 @default.
- W2916743695 cites W2750935355 @default.
- W2916743695 cites W2754708254 @default.
- W2916743695 cites W2755837499 @default.
- W2916743695 cites W2766785814 @default.
- W2916743695 cites W2774806607 @default.
- W2916743695 cites W2777258514 @default.
- W2916743695 cites W2779498364 @default.
- W2916743695 cites W2784190408 @default.
- W2916743695 cites W2791376381 @default.
- W2916743695 cites W2795436063 @default.
- W2916743695 cites W2801231640 @default.
- W2916743695 cites W2807099454 @default.
- W2916743695 cites W2808728877 @default.
- W2916743695 cites W2888618670 @default.
- W2916743695 cites W2900138047 @default.
- W2916743695 cites W2906243785 @default.