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• W2916758916 abstract "Abstract Breast cancer metastasis accounts for most of the deaths from breast cancer. Since epithelial-mesenchymal transition (EMT) plays an important role in promoting metastasis of cancer, many mechanisms regarding EMT have been studied. We previously showed that Ribonucleic acid export 1 (RAE1) is dysregulated in breast cancer and its overexpression leads to aggressive breast cancer phenotypes by inducing EMT. Here, we evaluated the functional capacity of RAE1 in breast cancer metastasis by using a three-dimensional (3D) culture system and xenograft models. Furthermore, to investigate the mechanisms of RAE1-driven EMT, in vitro studies were carried out. The induction of EMT with RAE1-overexpression was confirmed under the 3D culture system and in vivo system. Importantly, RAE1 mediates upregulation of an EMT marker ZEB1, by binding to the promoter region of ZEB1 . Knockdown of ZEB1 in RAE1-overexpressing cells suppressed invasive and migratory behaviors, accompanied by an increase in epithelial and a decrease in mesenchymal markers. Taken together, these data demonstrate that RAE1 contributes to breast cancer metastasis by regulating a key EMT-inducing factor ZEB1 expression, suggesting its potential as a therapeutic target." @default.
• W2916758916 created "2019-03-02" @default.
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• W2916758916 date "2019-02-27" @default.
• W2916758916 modified "2023-10-16" @default.
• W2916758916 title "RAE1 mediated ZEB1 expression promotes epithelial–mesenchymal transition in breast cancer" @default.
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• W2916758916 doi "https://doi.org/10.1038/s41598-019-39574-8" @default.
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• W2916758916 hasPublicationYear "2019" @default.
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