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• W29168012 abstract "During the initial surveys in search of viral infectious agents carried out in the late 1940s to the 1960s reovirus was discovered to be a common infectious agent that was recovered from the feces of virtually all mammals (Rosen and Abinanti 1960; Hrdy et al. 1979). In humans, exposure to the mammalian reovirus occurs in childhood, with a high proportion of the population having serological evidence of infection by young adulthood (Lerner et al. 1947; Jackson et al. 1961; Leers and Royce 1966). However, a role of reovirus in the pathogenesis of symptomatic infection has not been substantiated in humans. Although reoviruses have not been conclusively implicated in any human disease, this viral system has served as a model to study the manner by which other more pathogenic viruses in humans may infect the gut and gain entry into a mammalian host. The ability to manipulate the viral genetic elements has enhanced our ability to define viral proteins associated with virus delivery, entry, and infection at the primary site of entry and has been an additional rationale to study reovirus infection." @default.
• W29168012 created "2016-06-24" @default.
• W29168012 creator A5044918376 @default.
• W29168012 creator A5075870293 @default.
• W29168012 date "1998-01-01" @default.
• W29168012 modified "2023-09-26" @default.
• W29168012 title "Pathogenesis of Reovirus Gastrointestinal and Hepatobiliary Disease" @default.
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• W29168012 doi "https://doi.org/10.1007/978-3-642-72095-6_4" @default.
• W29168012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9599932" @default.
• W29168012 hasPublicationYear "1998" @default.
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