FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916820923> ?p ?o ?g. }

• W2916820923 abstract "Purpose To search for potential protein markers or activated pathways which play a role in ovarian cancer. Experimental procedures Serum of six patients with a serous adenocarcinoma of the ovary (stage IIIB or higher) was collected before treatment. Matched control patients with a serous cystadenoma of the ovary were chosen as a control group. In addition, homogeneous regions of cells that exhibited uniform histology were isolated from cancer tissue in three of these patients by laser capture microdissection (LCM), normal ovarian epithelial cell samples were taken from their matched controls. Subsequently we employed label-free liquid chromatography tandem mass spectrometry (LC-MS E ) to identify proteins and determine their absolute concentrations in serum specimens and tissue lysates. Moderated t-tests were used to identify differentially expressed proteins between patient- and control-group, p-values were adjusted for multiple-testing using Benjamini-Hochberg false discovery rates. Proteins were considered to be differentially expressed if the adjusted p-values were Summary of the data In the serum specimens, 13 differentially expressed proteins were identified by LC-MS E profiling. Proteins with different concentrations in patients versus control sera include abundant serum proteins such as apolipoprotein AI and transferrin, that both exhibited a lower concentration in serum of cancer patients. Differential expression was also observed for apolipoproteins (APOA IV, APOA II and APOC III) and other proteins that have not been associated with ovarian cancer previously such as C9 and Afamin. In the tissue lysates, 17 differentially expressed proteins were identified. Amounts of collagen found were decreased in cancer tissue. Furthermore, proteins associated with the respiratory chain and cell migration were found in increased amounts in the cancer tissue lysates. Interestingly, no overlap was found between the discriminatory proteins in serum specimens and corresponding tissue lysates, illustrating the challenge to identify a single biomarker in the circulation reflecting ovary cancer. Conclusions Our study revealed several protein changes in serum and the ovary of patients suffering from serous adenocarcinoma of the ovary (stage IIIB or higher). Further investigation of these proteins is warranted to establish whether they could provide new insights into the etiology of the disease and act as potential new disease markers. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3980." @default.
• W2916820923 created "2019-03-02" @default.
• W2916820923 creator A5002827739 @default.
• W2916820923 creator A5017331599 @default.
• W2916820923 creator A5023432101 @default.
• W2916820923 creator A5027561354 @default.
• W2916820923 creator A5027686533 @default.
• W2916820923 creator A5031398647 @default.
• W2916820923 creator A5041411121 @default.
• W2916820923 creator A5056249670 @default.
• W2916820923 creator A5085925712 @default.
• W2916820923 date "2010-04-15" @default.
• W2916820923 modified "2023-09-27" @default.
• W2916820923 title "Abstract 3980: Quantitative detection of discriminatory proteins in tissue and serum of ovarian cancer patients by LC-MSE" @default.
• W2916820923 doi "https://doi.org/10.1158/1538-7445.am10-3980" @default.
• W2916820923 hasPublicationYear "2010" @default.
• W2916820923 type Work @default.
• W2916820923 sameAs 2916820923 @default.
• W2916820923 citedByCount "0" @default.
• W2916820923 crossrefType "proceedings-article" @default.
• W2916820923 hasAuthorship W2916820923A5002827739 @default.
• W2916820923 hasAuthorship W2916820923A5017331599 @default.
• W2916820923 hasAuthorship W2916820923A5023432101 @default.
• W2916820923 hasAuthorship W2916820923A5027561354 @default.
• W2916820923 hasAuthorship W2916820923A5027686533 @default.
• W2916820923 hasAuthorship W2916820923A5031398647 @default.
• W2916820923 hasAuthorship W2916820923A5041411121 @default.
• W2916820923 hasAuthorship W2916820923A5056249670 @default.
• W2916820923 hasAuthorship W2916820923A5085925712 @default.
• W2916820923 hasConcept C104317684 @default.
• W2916820923 hasConcept C121608353 @default.
• W2916820923 hasConcept C125965507 @default.
• W2916820923 hasConcept C126322002 @default.
• W2916820923 hasConcept C134018914 @default.
• W2916820923 hasConcept C142724271 @default.
• W2916820923 hasConcept C146543888 @default.
• W2916820923 hasConcept C150173356 @default.
• W2916820923 hasConcept C150194340 @default.
• W2916820923 hasConcept C153911025 @default.
• W2916820923 hasConcept C2778324911 @default.
• W2916820923 hasConcept C2780427987 @default.
• W2916820923 hasConcept C2908988626 @default.
• W2916820923 hasConcept C46111723 @default.
• W2916820923 hasConcept C54355233 @default.
• W2916820923 hasConcept C55493867 @default.
• W2916820923 hasConcept C71924100 @default.
• W2916820923 hasConcept C86803240 @default.
• W2916820923 hasConceptScore W2916820923C104317684 @default.
• W2916820923 hasConceptScore W2916820923C121608353 @default.
• W2916820923 hasConceptScore W2916820923C125965507 @default.
• W2916820923 hasConceptScore W2916820923C126322002 @default.
• W2916820923 hasConceptScore W2916820923C134018914 @default.
• W2916820923 hasConceptScore W2916820923C142724271 @default.
• W2916820923 hasConceptScore W2916820923C146543888 @default.
• W2916820923 hasConceptScore W2916820923C150173356 @default.
• W2916820923 hasConceptScore W2916820923C150194340 @default.
• W2916820923 hasConceptScore W2916820923C153911025 @default.
• W2916820923 hasConceptScore W2916820923C2778324911 @default.
• W2916820923 hasConceptScore W2916820923C2780427987 @default.
• W2916820923 hasConceptScore W2916820923C2908988626 @default.
• W2916820923 hasConceptScore W2916820923C46111723 @default.
• W2916820923 hasConceptScore W2916820923C54355233 @default.
• W2916820923 hasConceptScore W2916820923C55493867 @default.
• W2916820923 hasConceptScore W2916820923C71924100 @default.
• W2916820923 hasConceptScore W2916820923C86803240 @default.
• W2916820923 hasLocation W29168209231 @default.
• W2916820923 hasOpenAccess W2916820923 @default.
• W2916820923 hasPrimaryLocation W29168209231 @default.
• W2916820923 hasRelatedWork W1962178031 @default.
• W2916820923 hasRelatedWork W1973372083 @default.
• W2916820923 hasRelatedWork W2007337075 @default.
• W2916820923 hasRelatedWork W2007864681 @default.
• W2916820923 hasRelatedWork W2013059825 @default.
• W2916820923 hasRelatedWork W2103065057 @default.
• W2916820923 hasRelatedWork W2111542018 @default.
• W2916820923 hasRelatedWork W2161595887 @default.
• W2916820923 hasRelatedWork W2171520870 @default.
• W2916820923 hasRelatedWork W2327512336 @default.
• W2916820923 hasRelatedWork W2338353975 @default.
• W2916820923 hasRelatedWork W2372023070 @default.
• W2916820923 hasRelatedWork W2398234705 @default.
• W2916820923 hasRelatedWork W2752949897 @default.
• W2916820923 hasRelatedWork W278989748 @default.
• W2916820923 hasRelatedWork W2919319482 @default.
• W2916820923 hasRelatedWork W2998920676 @default.
• W2916820923 hasRelatedWork W3015444891 @default.
• W2916820923 hasRelatedWork W3040636051 @default.
• W2916820923 hasRelatedWork W995880409 @default.
• W2916820923 isParatext "false" @default.
• W2916820923 isRetracted "false" @default.
• W2916820923 magId "2916820923" @default.
• W2916820923 workType "article" @default.