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• W2916828727 abstract "Most motile flagella have an axoneme that contains nine outer microtubule doublets and a central pair (CP) of microtubules. The CP coordinates the flagellar beat and defects in CP projections are associated with motility defects and human disease. The CP nucleate near a ‘basal plate’ at the distal end of the transition zone (TZ). Here, we show that the trypanosome TZ protein ‘basalin’ is essential for building the basal plate, and its loss is associated with CP nucleation defects, inefficient recruitment of CP assembly factors to the TZ, and flagellum paralysis. Guided by synteny, we identified a highly divergent basalin ortholog in the related Leishmania species. Basalins are predicted to be highly unstructured, suggesting they may act as ‘hubs’ facilitating many protein-protein interactions. This raises the general concept that proteins involved in cytoskeletal functions and appearing organism-specific, may have highly divergent and cryptic orthologs in other species." @default.
• W2916828727 created "2019-03-02" @default.
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• W2916828727 date "2019-02-27" @default.
• W2916828727 modified "2023-10-17" @default.
• W2916828727 title "Basalin is an evolutionarily unconstrained protein revealed via a conserved role in flagellum basal plate function" @default.
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• W2916828727 doi "https://doi.org/10.7554/elife.42282" @default.
• W2916828727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6392502" @default.
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