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• W2916838612 abstract "Multiparametric imaging is a critical tool in the noninvasive study and assessment of cancer. Imaging methods have evolved over the past several decades to provide quantitative measures of tumor and healthy tissue characteristics related to, for example, cell number, blood volume fraction, blood flow, hypoxia, and metabolism. Mechanistic models of tumor growth also have matured to a point where the incorporation of patient-specific measures could provide clinically relevant predictions of tumor growth and response. In this review, we identify and discuss approaches that use multiparametric imaging data, including diffusion-weighted magnetic resonance imaging, dynamic contrast-enhanced magnetic resonance imaging, diffusion tensor imaging, contrast-enhanced computed tomography, [18F]fluorodeoxyglucose positron emission tomography, and [18F]fluoromisonidazole positron emission tomography to initialize and calibrate mechanistic models of tumor growth and response. We focus the discussion on brain and breast cancers; however, we also identify three emerging areas of application in kidney, pancreatic, and lung cancers. We conclude with a discussion of the future directions for incorporating multiparametric imaging data and mechanistic modeling into clinical decision making for patients with cancer." @default.
• W2916838612 created "2019-03-02" @default.
• W2916838612 creator A5027619317 @default.
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• W2916838612 creator A5086875206 @default.
• W2916838612 date "2019-12-01" @default.
• W2916838612 modified "2023-10-18" @default.
• W2916838612 title "Mechanism-Based Modeling of Tumor Growth and Treatment Response Constrained by Multiparametric Imaging Data" @default.
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• W2916838612 doi "https://doi.org/10.1200/cci.18.00055" @default.
• W2916838612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6535803" @default.
• W2916838612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30807209" @default.

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