Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916844714> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2916844714 endingPage "112" @default.
- W2916844714 startingPage "109" @default.
- W2916844714 abstract "Sazetidine-A selectively desensitizes α4β2 nicotinic receptors and also has partial agonist effects. We have shown that subcutaneous acute and repeated injections as well as chronic infusions of sazetidine-A significantly reduce intravenous (IV) nicotine self-administration in rats. To further investigate the promise of sazetidine-A as a smoking cessation aid, it is important to determine sazetidine-A effects with oral administration and the time-effect function for its action on nicotine self-administration. Young adult female Sprague-Dawley rats were trained to self-administer IV nicotine at the benchmark dose of 0.03 mg/kg/infusion dose in an operant FR1 schedule in 45-min sessions. After five sessions of training, they were tested for the effects of acute oral doses of sazetidine-A (0, 0.3, 1 and 3 mg/kg) given 30 min before testing. To determine the time-effect function, these rats were administered 0 or 3 mg/kg of sazetidine-A 1, 2, 4 or 23 h before the onset of testing. Our previous study showed that with subcutaneous injections, only 3 mg/kg of sazetidine-A significantly reduced nicotine self-administration, however, with oral administration of sazetidine-A lower dose of 1 mg/kg was also effective in reducing nicotine intake. A similar effect was seen in the time-effect study with 3 mg/kg of oral sazetidine-A causing a significant reduction in nicotine self-administration across all the time points of 1, 2, 4 or 23 h after oral administration. These results advance the development of sazetidine-A as a possible aid for smoking cessation by showing effectiveness with oral administration and persistence of the effect over the course of a day." @default.
- W2916844714 created "2019-03-02" @default.
- W2916844714 creator A5004763783 @default.
- W2916844714 creator A5006057012 @default.
- W2916844714 creator A5028884366 @default.
- W2916844714 creator A5043967898 @default.
- W2916844714 creator A5062828124 @default.
- W2916844714 creator A5067748815 @default.
- W2916844714 date "2019-04-01" @default.
- W2916844714 modified "2023-10-16" @default.
- W2916844714 title "Oral sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, reduces nicotine self-administration in rats" @default.
- W2916844714 cites W1968544134 @default.
- W2916844714 cites W1971871392 @default.
- W2916844714 cites W1982378333 @default.
- W2916844714 cites W1985530197 @default.
- W2916844714 cites W1988168385 @default.
- W2916844714 cites W1988182239 @default.
- W2916844714 cites W1996239220 @default.
- W2916844714 cites W2007447520 @default.
- W2916844714 cites W2009285843 @default.
- W2916844714 cites W2061475648 @default.
- W2916844714 cites W2082362344 @default.
- W2916844714 cites W2085618103 @default.
- W2916844714 cites W2094009623 @default.
- W2916844714 cites W2101520329 @default.
- W2916844714 cites W2106076742 @default.
- W2916844714 cites W2109732014 @default.
- W2916844714 cites W2124166625 @default.
- W2916844714 cites W2133701994 @default.
- W2916844714 cites W2139385647 @default.
- W2916844714 cites W2164386461 @default.
- W2916844714 cites W2182368527 @default.
- W2916844714 cites W4240191731 @default.
- W2916844714 cites W4294833769 @default.
- W2916844714 doi "https://doi.org/10.1016/j.pbb.2019.02.007" @default.
- W2916844714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6570822" @default.
- W2916844714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30794849" @default.
- W2916844714 hasPublicationYear "2019" @default.
- W2916844714 type Work @default.
- W2916844714 sameAs 2916844714 @default.
- W2916844714 citedByCount "1" @default.
- W2916844714 countsByYear W29168447142022 @default.
- W2916844714 crossrefType "journal-article" @default.
- W2916844714 hasAuthorship W2916844714A5004763783 @default.
- W2916844714 hasAuthorship W2916844714A5006057012 @default.
- W2916844714 hasAuthorship W2916844714A5028884366 @default.
- W2916844714 hasAuthorship W2916844714A5043967898 @default.
- W2916844714 hasAuthorship W2916844714A5062828124 @default.
- W2916844714 hasAuthorship W2916844714A5067748815 @default.
- W2916844714 hasBestOaLocation W29168447142 @default.
- W2916844714 hasConcept C126322002 @default.
- W2916844714 hasConcept C142724271 @default.
- W2916844714 hasConcept C170493617 @default.
- W2916844714 hasConcept C188987157 @default.
- W2916844714 hasConcept C2777056448 @default.
- W2916844714 hasConcept C2777843972 @default.
- W2916844714 hasConcept C2778555786 @default.
- W2916844714 hasConcept C2778938600 @default.
- W2916844714 hasConcept C2779547902 @default.
- W2916844714 hasConcept C42219234 @default.
- W2916844714 hasConcept C71924100 @default.
- W2916844714 hasConcept C98274493 @default.
- W2916844714 hasConceptScore W2916844714C126322002 @default.
- W2916844714 hasConceptScore W2916844714C142724271 @default.
- W2916844714 hasConceptScore W2916844714C170493617 @default.
- W2916844714 hasConceptScore W2916844714C188987157 @default.
- W2916844714 hasConceptScore W2916844714C2777056448 @default.
- W2916844714 hasConceptScore W2916844714C2777843972 @default.
- W2916844714 hasConceptScore W2916844714C2778555786 @default.
- W2916844714 hasConceptScore W2916844714C2778938600 @default.
- W2916844714 hasConceptScore W2916844714C2779547902 @default.
- W2916844714 hasConceptScore W2916844714C42219234 @default.
- W2916844714 hasConceptScore W2916844714C71924100 @default.
- W2916844714 hasConceptScore W2916844714C98274493 @default.
- W2916844714 hasFunder F4320337347 @default.
- W2916844714 hasLocation W29168447141 @default.
- W2916844714 hasLocation W29168447142 @default.
- W2916844714 hasLocation W29168447143 @default.
- W2916844714 hasOpenAccess W2916844714 @default.
- W2916844714 hasPrimaryLocation W29168447141 @default.
- W2916844714 hasRelatedWork W2007447520 @default.
- W2916844714 hasRelatedWork W2019718444 @default.
- W2916844714 hasRelatedWork W2038364744 @default.
- W2916844714 hasRelatedWork W2059950085 @default.
- W2916844714 hasRelatedWork W2065104981 @default.
- W2916844714 hasRelatedWork W2066998306 @default.
- W2916844714 hasRelatedWork W2097322630 @default.
- W2916844714 hasRelatedWork W2105726924 @default.
- W2916844714 hasRelatedWork W2139729598 @default.
- W2916844714 hasRelatedWork W2556850407 @default.
- W2916844714 hasVolume "179" @default.
- W2916844714 isParatext "false" @default.
- W2916844714 isRetracted "false" @default.
- W2916844714 magId "2916844714" @default.
- W2916844714 workType "article" @default.