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- W291684815 abstract "This chapter deals with the division potential of different cell types in vivo, and with the factors that may be responsible for some of the unexplained differences that are found in the culturing cells of different origins. The behavior of cultured normal epithelial cells is of particular importance for the in vitro study of carcinoma, because it is only occasionally that permanent human carcinoma cell lines can be established, using current methodology. The chapter discusses whether carcinoma cells in vivo have unlimited growth potential, as is usually assumed to be the case. Biologically and kinetically there is no need for such an assumption because a limited number of cell divisions in an expanding population of logarithmically dividing cells are quite sufficient for very large amounts of tumor tissue. Division potential in renewing epithelia is potentially instructive in understanding the biology of the carcinoma cell. There is evidence that several stem cell populations may be in continuous rapid division throughout the lifetime of the organism, requiring a very high limit of division potential and perhaps no limit at all. This possibility is a subject of study in human material and might yield very instructive results." @default.
- W291684815 created "2016-06-24" @default.
- W291684815 creator A5009444556 @default.
- W291684815 date "1975-01-01" @default.
- W291684815 modified "2023-09-27" @default.
- W291684815 title "Epithelial Cells: Growth in Culture of Normal and Neoplastic Forms" @default.
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- W291684815 doi "https://doi.org/10.1016/s0065-230x(08)60974-4" @default.
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