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• W2916848801 endingPage "932" @default.
• W2916848801 startingPage "921" @default.
• W2916848801 abstract "NIR spectroscopy is a non-destructive tool for in-situ, on-line bioprocess monitoring. One of its most frequent applications is the determination of metabolites during cultivation, especially glucose. Previous studies have usually investigated the applicability of Near Infrared (NIR) spectroscopy at one bioreactor scale but the effect of scale up was not explored. In this study, the complete scale up from shake flask (1 L) through 20 L, 100 L and 1000 L up to 5000 L bioreactor volume level was monitored with on-line NIR spectroscopy. The differences between runs and scales were examined using principal component analysis. The bioreactor runs were relatively similar regardless of scales but the shake flasks differed strongly from bioreactor runs. The glucose concentration throughout five 5000 L scale bioreactor runs were predicted by partial least squares regression models that were based on pre-processed spectra of bioreactor runs and combinations of them. The model that produced the lowest error of prediction (4.18 mM on a 29 mM concentration range) for all five runs in the prediction set was based on the combination of 20 L and 100 L data. This result demonstrated the capabilities and the limitations of an NIR system for glucose monitoring in mammalian cell cultivations." @default.
• W2916848801 created "2019-03-02" @default.
• W2916848801 creator A5001679699 @default.
• W2916848801 creator A5013692657 @default.
• W2916848801 creator A5062271866 @default.
• W2916848801 date "2019-02-26" @default.
• W2916848801 modified "2023-10-04" @default.
• W2916848801 title "On-line glucose monitoring by near infrared spectroscopy during the scale up steps of mammalian cell cultivation process development" @default.
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• W2916848801 doi "https://doi.org/10.1007/s00449-019-02091-z" @default.
• W2916848801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6527534" @default.
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• W2916848801 hasPublicationYear "2019" @default.
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