Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916857182> ?p ?o ?g. }
- W2916857182 endingPage "e3000016" @default.
- W2916857182 startingPage "e3000016" @default.
- W2916857182 abstract "Studying aneuploidy during organism development has strong limitations because chronic mitotic perturbations used to generate aneuploidy usually result in lethality. We developed a genetic tool to induce aneuploidy in an acute and time-controlled manner during Drosophila development. This is achieved by reversible depletion of cohesin, a key molecule controlling mitotic fidelity. Larvae challenged with aneuploidy hatch into adults with severe motor defects shortening their life span. Neural stem cells, despite being aneuploid, display a delayed stress response and continue proliferating, resulting in the rapid appearance of chromosomal instability, a complex array of karyotypes, and cellular abnormalities. Notably, when other brain-cell lineages are forced to self-renew, aneuploidy-associated stress response is significantly delayed. Protecting only the developing brain from induced aneuploidy is sufficient to rescue motor defects and adult life span, suggesting that neural tissue is the most ill-equipped to deal with developmental aneuploidy." @default.
- W2916857182 created "2019-03-02" @default.
- W2916857182 creator A5030645496 @default.
- W2916857182 creator A5035825838 @default.
- W2916857182 creator A5063444080 @default.
- W2916857182 creator A5063635149 @default.
- W2916857182 creator A5080862064 @default.
- W2916857182 date "2019-02-22" @default.
- W2916857182 modified "2023-10-01" @default.
- W2916857182 title "Induced aneuploidy in neural stem cells triggers a delayed stress response and impairs adult life span in flies" @default.
- W2916857182 cites W1529561783 @default.
- W2916857182 cites W1529934215 @default.
- W2916857182 cites W1558701786 @default.
- W2916857182 cites W1890766043 @default.
- W2916857182 cites W1924895133 @default.
- W2916857182 cites W1965707365 @default.
- W2916857182 cites W1969348568 @default.
- W2916857182 cites W1970903683 @default.
- W2916857182 cites W1971013077 @default.
- W2916857182 cites W1973394316 @default.
- W2916857182 cites W1977793938 @default.
- W2916857182 cites W1978433149 @default.
- W2916857182 cites W1983340499 @default.
- W2916857182 cites W1983579777 @default.
- W2916857182 cites W1984103917 @default.
- W2916857182 cites W1991100707 @default.
- W2916857182 cites W1991689596 @default.
- W2916857182 cites W1993115402 @default.
- W2916857182 cites W2001857879 @default.
- W2916857182 cites W2002470273 @default.
- W2916857182 cites W2005184738 @default.
- W2916857182 cites W2019077723 @default.
- W2916857182 cites W2025693577 @default.
- W2916857182 cites W2032629746 @default.
- W2916857182 cites W2040461990 @default.
- W2916857182 cites W2042882869 @default.
- W2916857182 cites W2052484458 @default.
- W2916857182 cites W2062214822 @default.
- W2916857182 cites W2064182959 @default.
- W2916857182 cites W2066803056 @default.
- W2916857182 cites W2068129662 @default.
- W2916857182 cites W2073931069 @default.
- W2916857182 cites W2075754851 @default.
- W2916857182 cites W2076201716 @default.
- W2916857182 cites W2089124709 @default.
- W2916857182 cites W2091502861 @default.
- W2916857182 cites W2096000713 @default.
- W2916857182 cites W2097363543 @default.
- W2916857182 cites W2100300374 @default.
- W2916857182 cites W2102502996 @default.
- W2916857182 cites W2110468545 @default.
- W2916857182 cites W2110691960 @default.
- W2916857182 cites W2121094803 @default.
- W2916857182 cites W2129319315 @default.
- W2916857182 cites W2138542158 @default.
- W2916857182 cites W2144999008 @default.
- W2916857182 cites W2146112493 @default.
- W2916857182 cites W2151068428 @default.
- W2916857182 cites W2157480976 @default.
- W2916857182 cites W2167279371 @default.
- W2916857182 cites W2181226250 @default.
- W2916857182 cites W2189135309 @default.
- W2916857182 cites W2207973449 @default.
- W2916857182 cites W2243837007 @default.
- W2916857182 cites W2315765031 @default.
- W2916857182 cites W2324329488 @default.
- W2916857182 cites W2352719856 @default.
- W2916857182 cites W2426804180 @default.
- W2916857182 cites W2460541450 @default.
- W2916857182 cites W2518846635 @default.
- W2916857182 cites W2573221347 @default.
- W2916857182 cites W2601185723 @default.
- W2916857182 cites W2604944651 @default.
- W2916857182 cites W2674549768 @default.
- W2916857182 cites W2691929059 @default.
- W2916857182 cites W2693925639 @default.
- W2916857182 cites W2745860177 @default.
- W2916857182 cites W2761461280 @default.
- W2916857182 cites W2771292125 @default.
- W2916857182 cites W2795173023 @default.
- W2916857182 cites W2800736951 @default.
- W2916857182 cites W2895152750 @default.
- W2916857182 cites W2952092894 @default.
- W2916857182 cites W2991898884 @default.
- W2916857182 doi "https://doi.org/10.1371/journal.pbio.3000016" @default.
- W2916857182 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6402706" @default.
- W2916857182 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30794535" @default.
- W2916857182 hasPublicationYear "2019" @default.
- W2916857182 type Work @default.
- W2916857182 sameAs 2916857182 @default.
- W2916857182 citedByCount "12" @default.
- W2916857182 countsByYear W29168571822019 @default.
- W2916857182 countsByYear W29168571822020 @default.
- W2916857182 countsByYear W29168571822021 @default.
- W2916857182 countsByYear W29168571822022 @default.
- W2916857182 countsByYear W29168571822023 @default.
- W2916857182 crossrefType "journal-article" @default.
- W2916857182 hasAuthorship W2916857182A5030645496 @default.