Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916865346> ?p ?o ?g. }
- W2916865346 endingPage "1283" @default.
- W2916865346 startingPage "1275" @default.
- W2916865346 abstract "Abstract NK cells are lymphocytes of the innate immune system, which are able to deal promptly with stressed cells. Cellular senescence is a cell stress response leading to cell cycle arrest that plays a key role during tissue homeostasis and carcinogenesis. In this review, how senescent cells trigger an immune response and, in particular, the ability of NK cells to recognize and clear senescent cells are discussed. Special attention is given to the NK cell-mediated clearance of senescent tumor cells. NK cells kill senescent cells through a mechanism involving perforin- and granzyme-containing granule exocytosis, and produce IFN-γ following senescent cell interaction, leading to hypothesize that NK cell-mediated immune clearance of senescent cells not only relies on direct killing but also on cytokine production, that in turn can promote macrophage activation. These aspects, as well as the ability of the senescence-associated secretory phenotype and senescent cell-produced extracellular vesicles to modulate NK cell effector functions, are described." @default.
- W2916865346 created "2019-03-02" @default.
- W2916865346 creator A5024871281 @default.
- W2916865346 creator A5063846820 @default.
- W2916865346 creator A5074159017 @default.
- W2916865346 creator A5086891953 @default.
- W2916865346 date "2019-02-27" @default.
- W2916865346 modified "2023-10-01" @default.
- W2916865346 title "Senescent cells: Living or dying is a matter of NK cells" @default.
- W2916865346 cites W1487745522 @default.
- W2916865346 cites W1587153999 @default.
- W2916865346 cites W1643050643 @default.
- W2916865346 cites W1800944583 @default.
- W2916865346 cites W1966798507 @default.
- W2916865346 cites W1968460020 @default.
- W2916865346 cites W1969464492 @default.
- W2916865346 cites W1976635482 @default.
- W2916865346 cites W1977362098 @default.
- W2916865346 cites W1980638418 @default.
- W2916865346 cites W1982192597 @default.
- W2916865346 cites W1990680524 @default.
- W2916865346 cites W1993856276 @default.
- W2916865346 cites W1997893106 @default.
- W2916865346 cites W2004273407 @default.
- W2916865346 cites W2005202415 @default.
- W2916865346 cites W2010004911 @default.
- W2916865346 cites W2011997876 @default.
- W2916865346 cites W2015665286 @default.
- W2916865346 cites W2020404158 @default.
- W2916865346 cites W2021163182 @default.
- W2916865346 cites W2023283620 @default.
- W2916865346 cites W2026890342 @default.
- W2916865346 cites W2027267479 @default.
- W2916865346 cites W2028671480 @default.
- W2916865346 cites W2042037279 @default.
- W2916865346 cites W2042140414 @default.
- W2916865346 cites W2044341880 @default.
- W2916865346 cites W2045055958 @default.
- W2916865346 cites W2045939728 @default.
- W2916865346 cites W2047119143 @default.
- W2916865346 cites W2050852029 @default.
- W2916865346 cites W2052388837 @default.
- W2916865346 cites W2057619489 @default.
- W2916865346 cites W2069519394 @default.
- W2916865346 cites W2083439589 @default.
- W2916865346 cites W2090067193 @default.
- W2916865346 cites W2099782488 @default.
- W2916865346 cites W2103872250 @default.
- W2916865346 cites W2116842394 @default.
- W2916865346 cites W2124116044 @default.
- W2916865346 cites W2128807350 @default.
- W2916865346 cites W2130458932 @default.
- W2916865346 cites W2131078803 @default.
- W2916865346 cites W2131974830 @default.
- W2916865346 cites W2132224453 @default.
- W2916865346 cites W2144201925 @default.
- W2916865346 cites W2145578278 @default.
- W2916865346 cites W2146783950 @default.
- W2916865346 cites W2146784968 @default.
- W2916865346 cites W2149295658 @default.
- W2916865346 cites W2150740687 @default.
- W2916865346 cites W2150748567 @default.
- W2916865346 cites W2156119355 @default.
- W2916865346 cites W2161729567 @default.
- W2916865346 cites W2163586656 @default.
- W2916865346 cites W2165259537 @default.
- W2916865346 cites W2167244325 @default.
- W2916865346 cites W2181262244 @default.
- W2916865346 cites W2217986049 @default.
- W2916865346 cites W2224886002 @default.
- W2916865346 cites W2237743540 @default.
- W2916865346 cites W2266290735 @default.
- W2916865346 cites W2283668976 @default.
- W2916865346 cites W2300472255 @default.
- W2916865346 cites W2311703219 @default.
- W2916865346 cites W2319232270 @default.
- W2916865346 cites W2337235966 @default.
- W2916865346 cites W2346866879 @default.
- W2916865346 cites W2411937682 @default.
- W2916865346 cites W2426149297 @default.
- W2916865346 cites W2499070802 @default.
- W2916865346 cites W2510573592 @default.
- W2916865346 cites W2516421314 @default.
- W2916865346 cites W2530995434 @default.
- W2916865346 cites W2549164857 @default.
- W2916865346 cites W2550556018 @default.
- W2916865346 cites W2553534905 @default.
- W2916865346 cites W2553684548 @default.
- W2916865346 cites W2572507869 @default.
- W2916865346 cites W2583634043 @default.
- W2916865346 cites W2587149647 @default.
- W2916865346 cites W2599353531 @default.
- W2916865346 cites W2604022024 @default.
- W2916865346 cites W2609769996 @default.
- W2916865346 cites W2612090342 @default.
- W2916865346 cites W2613244654 @default.
- W2916865346 cites W2618634776 @default.
- W2916865346 cites W2620914886 @default.