FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916866510> ?p ?o ?g. }

• W2916866510 endingPage "201" @default.
• W2916866510 startingPage "193" @default.
• W2916866510 abstract "The contamination of the environment with human pharmaceuticals is widespread and demand for such products is mounting globally. Wild vertebrates may be at particular risk from any effects from pharmaceuticals, because of the evolutionary conservation of drug targets. However, exposure of wildlife to pharmaceuticals is poorly characterised, partly due to challenges associated with detecting rapidly metabolised compounds. As part of a wider study on the behavioural effects of fluoxetine (Prozac) on Eurasian starlings (Sturnus vulgaris), we investigated which avian samples are best suited for detecting exposure to fluoxetine in free-living birds. We analysed plasma, various tissues and tail feathers (grown both in the wild and in captivity during the dosing period) from fluoxetine-treated birds (dosed daily with 0.035 mg kg−1 bodyweight for 28 weeks), and liver tissue and tail feathers from sham-dosed birds. We detected fluoxetine in only two of twelve plasma samples from dosed birds. In dosed birds, median concentrations of free fluoxetine/norfluoxetine in tissues (two hour post-final dose) were: 111.2/67.6 ng g−1 in liver, 29.6/5.7 ng g−1 in kidney, 14.2/4.0 ng g−1 in lung, 15.1/1.6 ng g−1 in brain. We estimated that fluoxetine would remain detectable in liver and kidney approximately 4.5 times longer (90 h) than in brain (20h). In dosed birds, fluoxetine was detected in feathers regrown during the dosing period (median concentration = 11.4 ng g−1) at concentrations significantly higher than in regrown feathers from control birds. Fluoxetine residues were detected in wild-grown feathers (grown before the birds were brought into captivity) at concentrations up to 27.0 ng g−1, providing some evidence of likely exposure in the wild. Our results show liver and kidney can be used for detecting fluoxetine in avian carcasses and provide a first indication that feathers may be useful for assessing exposure to fluoxetine, and possibly other pharmaceuticals." @default.
• W2916866510 created "2019-03-02" @default.
• W2916866510 creator A5001988009 @default.
• W2916866510 creator A5018740706 @default.
• W2916866510 creator A5052361766 @default.
• W2916866510 creator A5053539616 @default.
• W2916866510 creator A5071040166 @default.
• W2916866510 creator A5081869094 @default.
• W2916866510 date "2019-05-01" @default.
• W2916866510 modified "2023-10-02" @default.
• W2916866510 title "Detecting fluoxetine and norfluoxetine in wild bird tissues and feathers" @default.
• W2916866510 cites W1577645519 @default.
• W2916866510 cites W1820142933 @default.
• W2916866510 cites W1966206163 @default.
• W2916866510 cites W1966759773 @default.
• W2916866510 cites W1967522520 @default.
• W2916866510 cites W1979452048 @default.
• W2916866510 cites W1990223231 @default.
• W2916866510 cites W1991378131 @default.
• W2916866510 cites W1993063613 @default.
• W2916866510 cites W2003280048 @default.
• W2916866510 cites W2008124122 @default.
• W2916866510 cites W2014783575 @default.
• W2916866510 cites W2024653634 @default.
• W2916866510 cites W2026765020 @default.
• W2916866510 cites W2039289294 @default.
• W2916866510 cites W2039810735 @default.
• W2916866510 cites W2050101749 @default.
• W2916866510 cites W2053322034 @default.
• W2916866510 cites W2062273830 @default.
• W2916866510 cites W2064661722 @default.
• W2916866510 cites W2069245531 @default.
• W2916866510 cites W2083961981 @default.
• W2916866510 cites W2084746559 @default.
• W2916866510 cites W2086414339 @default.
• W2916866510 cites W2090977130 @default.
• W2916866510 cites W2092046290 @default.
• W2916866510 cites W2095867462 @default.
• W2916866510 cites W2104105182 @default.
• W2916866510 cites W2126247577 @default.
• W2916866510 cites W2140102221 @default.
• W2916866510 cites W2151745588 @default.
• W2916866510 cites W2155601190 @default.
• W2916866510 cites W2156822348 @default.
• W2916866510 cites W2159284216 @default.
• W2916866510 cites W2162306592 @default.
• W2916866510 cites W2168129859 @default.
• W2916866510 cites W2288369054 @default.
• W2916866510 cites W2331170631 @default.
• W2916866510 cites W2512276647 @default.
• W2916866510 cites W2588378651 @default.
• W2916866510 cites W2762640941 @default.
• W2916866510 cites W2883783287 @default.
• W2916866510 doi "https://doi.org/10.1016/j.envint.2019.01.083" @default.
• W2916866510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30802636" @default.
• W2916866510 hasPublicationYear "2019" @default.
• W2916866510 type Work @default.
• W2916866510 sameAs 2916866510 @default.
• W2916866510 citedByCount "12" @default.
• W2916866510 countsByYear W29168665102019 @default.
• W2916866510 countsByYear W29168665102020 @default.
• W2916866510 countsByYear W29168665102022 @default.
• W2916866510 countsByYear W29168665102023 @default.
• W2916866510 crossrefType "journal-article" @default.
• W2916866510 hasAuthorship W2916866510A5001988009 @default.
• W2916866510 hasAuthorship W2916866510A5018740706 @default.
• W2916866510 hasAuthorship W2916866510A5052361766 @default.
• W2916866510 hasAuthorship W2916866510A5053539616 @default.
• W2916866510 hasAuthorship W2916866510A5071040166 @default.
• W2916866510 hasAuthorship W2916866510A5081869094 @default.
• W2916866510 hasBestOaLocation W29168665101 @default.
• W2916866510 hasConcept C115346097 @default.
• W2916866510 hasConcept C126322002 @default.
• W2916866510 hasConcept C127745971 @default.
• W2916866510 hasConcept C134018914 @default.
• W2916866510 hasConcept C140793950 @default.
• W2916866510 hasConcept C170493617 @default.
• W2916866510 hasConcept C2775864247 @default.
• W2916866510 hasConcept C2776134451 @default.
• W2916866510 hasConcept C2776787076 @default.
• W2916866510 hasConcept C2779627344 @default.
• W2916866510 hasConcept C2780091579 @default.
• W2916866510 hasConcept C33070731 @default.
• W2916866510 hasConcept C42407357 @default.
• W2916866510 hasConcept C55493867 @default.
• W2916866510 hasConcept C71924100 @default.
• W2916866510 hasConcept C86803240 @default.
• W2916866510 hasConcept C90856448 @default.
• W2916866510 hasConcept C98274493 @default.
• W2916866510 hasConceptScore W2916866510C115346097 @default.
• W2916866510 hasConceptScore W2916866510C126322002 @default.
• W2916866510 hasConceptScore W2916866510C127745971 @default.
• W2916866510 hasConceptScore W2916866510C134018914 @default.
• W2916866510 hasConceptScore W2916866510C140793950 @default.
• W2916866510 hasConceptScore W2916866510C170493617 @default.
• W2916866510 hasConceptScore W2916866510C2775864247 @default.
• W2916866510 hasConceptScore W2916866510C2776134451 @default.
• W2916866510 hasConceptScore W2916866510C2776787076 @default.

• next