FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916914339> ?p ?o ?g. }

• W2916914339 endingPage "6654" @default.
• W2916914339 startingPage "6643" @default.
• W2916914339 abstract "The fetus is dependent on delivery of fatty acids (FAs) by the syncytiotrophoblast, the transporting epithelium of the human placenta. Obese pregnant women have dyslipidemia; however, whether obesity impacts placental lipid transport and metabolism remains to be fully established. Palmitoleic acid (POA), an FA with anti-inflammatory and insulin-sensitizing properties, is synthesized from palmitic acid (PA) catalyzed by stearoyl-coenzyme A desaturase (SCD) activity. We hypothesized that the uptake and incorporation of FAs and POA synthesis are reduced in primary human trophoblasts (PHTs) isolated from pregnancies complicated by maternal obesity. Villous cytotrophoblasts were isolated from 7 placentas of obese [body mass index (BMI) = 37.5 ± 1.9] and 12 normal (BMI = 23.6 ± 0.6) mothers. FA uptake and incorporation were assessed using uniformly labeled (U[13C])-FA mixtures of PA, oleic acid (OA), linoleic acid, and docosahexaenoic acid. Cellular [13C] FAs were quantified both in total cellular lipids and in lipid classes by GC-MS. Uptake and incorporation of [13C] FAs in total cellular lipids were not different in PHTs isolated from obese mothers compared with normal mothers. Only the concentration of OA was increased in the triglyceride fraction (P < 0.05) if the mother was obese. We found an isotopic enrichment of POA after U[13C]-PA treatment, demonstrating SCD activity in PHT cells. Labeled POA content and the POA:PA ratio were significantly lower in PHTs isolated from placentas of obese mothers compared with normal, healthy controls. Decreased syncytiotrophoblast POA synthesis may contribute to insulin resistance and low-grade inflammation in the mother, placenta, or fetus (or a combination of the 3) in pregnancies complicated by obesity.-Ferchaud-Roucher, V., Barner, K., Jansson, T., Powell, T. L. Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties." @default.
• W2916914339 created "2019-03-02" @default.
• W2916914339 creator A5024848351 @default.
• W2916914339 creator A5042085828 @default.
• W2916914339 creator A5068691304 @default.
• W2916914339 creator A5087459010 @default.
• W2916914339 date "2019-02-27" @default.
• W2916914339 modified "2023-09-26" @default.
• W2916914339 title "Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti‐inflammatory and insulin‐sensitizing properties" @default.
• W2916914339 cites W1585246110 @default.
• W2916914339 cites W1915498150 @default.
• W2916914339 cites W1971246106 @default.
• W2916914339 cites W1973796897 @default.
• W2916914339 cites W1982389973 @default.
• W2916914339 cites W1984362111 @default.
• W2916914339 cites W1988507644 @default.
• W2916914339 cites W2001346087 @default.
• W2916914339 cites W2003273828 @default.
• W2916914339 cites W2007106585 @default.
• W2916914339 cites W2010779359 @default.
• W2916914339 cites W2012929164 @default.
• W2916914339 cites W2029761858 @default.
• W2916914339 cites W2045159219 @default.
• W2916914339 cites W2047812052 @default.
• W2916914339 cites W2048451018 @default.
• W2916914339 cites W2051966703 @default.
• W2916914339 cites W2053307994 @default.
• W2916914339 cites W2054499954 @default.
• W2916914339 cites W2084023408 @default.
• W2916914339 cites W2087573020 @default.
• W2916914339 cites W2088044155 @default.
• W2916914339 cites W2088060242 @default.
• W2916914339 cites W2089255318 @default.
• W2916914339 cites W2103013051 @default.
• W2916914339 cites W2103467021 @default.
• W2916914339 cites W2107832644 @default.
• W2916914339 cites W2112684406 @default.
• W2916914339 cites W2113432131 @default.
• W2916914339 cites W2115327724 @default.
• W2916914339 cites W2119491472 @default.
• W2916914339 cites W2130377792 @default.
• W2916914339 cites W2136014653 @default.
• W2916914339 cites W2138202978 @default.
• W2916914339 cites W2139504574 @default.
• W2916914339 cites W2140619213 @default.
• W2916914339 cites W2148095099 @default.
• W2916914339 cites W2160827694 @default.
• W2916914339 cites W2164678700 @default.
• W2916914339 cites W2169869070 @default.
• W2916914339 cites W2170651583 @default.
• W2916914339 cites W2281155896 @default.
• W2916914339 cites W2412626606 @default.
• W2916914339 cites W2545876255 @default.
• W2916914339 cites W2557347242 @default.
• W2916914339 cites W2571799777 @default.
• W2916914339 cites W2618931991 @default.
• W2916914339 cites W2622594530 @default.
• W2916914339 cites W2886814696 @default.
• W2916914339 cites W2903693673 @default.
• W2916914339 doi "https://doi.org/10.1096/fj.201802444r" @default.
• W2916914339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6463919" @default.
• W2916914339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30811959" @default.
• W2916914339 hasPublicationYear "2019" @default.
• W2916914339 type Work @default.
• W2916914339 sameAs 2916914339 @default.
• W2916914339 citedByCount "13" @default.
• W2916914339 countsByYear W29169143392020 @default.
• W2916914339 countsByYear W29169143392021 @default.
• W2916914339 countsByYear W29169143392022 @default.
• W2916914339 countsByYear W29169143392023 @default.
• W2916914339 crossrefType "journal-article" @default.
• W2916914339 hasAuthorship W2916914339A5024848351 @default.
• W2916914339 hasAuthorship W2916914339A5042085828 @default.
• W2916914339 hasAuthorship W2916914339A5068691304 @default.
• W2916914339 hasAuthorship W2916914339A5087459010 @default.
• W2916914339 hasBestOaLocation W29169143391 @default.
• W2916914339 hasConcept C126322002 @default.
• W2916914339 hasConcept C134018914 @default.
• W2916914339 hasConcept C172680121 @default.
• W2916914339 hasConcept C185592680 @default.
• W2916914339 hasConcept C19038510 @default.
• W2916914339 hasConcept C2776953305 @default.
• W2916914339 hasConcept C2777171753 @default.
• W2916914339 hasConcept C2777391703 @default.
• W2916914339 hasConcept C2778096610 @default.
• W2916914339 hasConcept C2779234561 @default.
• W2916914339 hasConcept C2779306644 @default.
• W2916914339 hasConcept C2779315647 @default.
• W2916914339 hasConcept C2779641957 @default.
• W2916914339 hasConcept C2780809830 @default.
• W2916914339 hasConcept C2781403372 @default.
• W2916914339 hasConcept C4733338 @default.
• W2916914339 hasConcept C511355011 @default.
• W2916914339 hasConcept C543025807 @default.
• W2916914339 hasConcept C54355233 @default.
• W2916914339 hasConcept C55493867 @default.
• W2916914339 hasConcept C71924100 @default.
• W2916914339 hasConcept C86803240 @default.

• next