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• W2916929611 abstract "Lithium, a well-known inhibitor of glycogen synthase kinase-3β (GSK3β), can improve bone formation by activating the Wnt/β-catenin signalling pathway. However, most studies have used higher doses of lithium, which potentially have adverse effects. Herein, we report that low dose lithium supplementation (10 mg/kg/d for 6 weeks) in mice results in a serum lithium concentration of 0.02 mM significantly inhibiting GSK3β while activating Wnt/β-catenin in bone. In turn, we observed a significant increase in the expression of osteoprotegerin (OPG), with unaltered expression of nuclear-factor kβ ligand (RANKL), ultimately leading to a significant increase in the OPG/RANKL ratio. Altogether, our findings provide initial evidence that low dose lithium supplementation can promote the signalling pathways associated with bone formation." @default.
• W2916929611 created "2019-03-02" @default.
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• W2916929611 date "2019-04-01" @default.
• W2916929611 modified "2023-10-06" @default.
• W2916929611 title "Low dose lithium supplementation activates Wnt/β-catenin signalling and increases bone OPG/RANKL ratio in mice" @default.
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• W2916929611 doi "https://doi.org/10.1016/j.bbrc.2019.02.066" @default.
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