Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916948692> ?p ?o ?g. }
- W2916948692 abstract "Abstract Interleukin 1β (IL-1β) is upregulated following tendon injury. Here we demonstrate that in adult and fetal tenocytes IL-1β increases the expression of matrix metalloproteinases, tenascin-C and Sox9 and decreases the expression of scleraxis and cartilage oligomeric matrix protein. When cultured in 3-dimensional collagen gels adult and fetal tenocytes exposed to IL-1β have reduced contraction ability and generate tendon-like constructs with a lower storage modulus. In contrast, equine embryonic stem cell (ESC) derived tenocytes exposed to IL-1β exhibit no changes in gene expression and generate identical tendon-like constructs. We propose that ESC-derived tenocytes do not respond to IL-1β due to their low expression of interleukin 1 (IL-1) receptor 1 and high expression of the decoy receptor IL-1 receptor 2 and IL-1 receptor antagonist protein (IL1Ra). This may make ESC-derived tenocytes an advantageous source of cells for tissue regeneration and allow the development of novel pharmaceutical interventions to protect endogenous cells from inflammation." @default.
- W2916948692 created "2019-03-02" @default.
- W2916948692 creator A5000535977 @default.
- W2916948692 creator A5001012761 @default.
- W2916948692 creator A5002492534 @default.
- W2916948692 creator A5009344795 @default.
- W2916948692 creator A5082726741 @default.
- W2916948692 creator A5088864353 @default.
- W2916948692 date "2019-02-26" @default.
- W2916948692 modified "2023-10-12" @default.
- W2916948692 title "A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta" @default.
- W2916948692 cites W106175682 @default.
- W2916948692 cites W1148638342 @default.
- W2916948692 cites W1590546703 @default.
- W2916948692 cites W1607472423 @default.
- W2916948692 cites W1810967695 @default.
- W2916948692 cites W1913280318 @default.
- W2916948692 cites W1915518296 @default.
- W2916948692 cites W1921759467 @default.
- W2916948692 cites W1954024552 @default.
- W2916948692 cites W1968639212 @default.
- W2916948692 cites W1973207932 @default.
- W2916948692 cites W1984729535 @default.
- W2916948692 cites W1985525204 @default.
- W2916948692 cites W1986843662 @default.
- W2916948692 cites W1990008900 @default.
- W2916948692 cites W1992040788 @default.
- W2916948692 cites W1992245888 @default.
- W2916948692 cites W1999455903 @default.
- W2916948692 cites W1999779598 @default.
- W2916948692 cites W2001221672 @default.
- W2916948692 cites W2008406252 @default.
- W2916948692 cites W2019827038 @default.
- W2916948692 cites W2020280797 @default.
- W2916948692 cites W2023507189 @default.
- W2916948692 cites W2025589346 @default.
- W2916948692 cites W2031721046 @default.
- W2916948692 cites W2033685719 @default.
- W2916948692 cites W2034598927 @default.
- W2916948692 cites W2034786302 @default.
- W2916948692 cites W2036275556 @default.
- W2916948692 cites W2039388529 @default.
- W2916948692 cites W2041005727 @default.
- W2916948692 cites W2041231786 @default.
- W2916948692 cites W2043024818 @default.
- W2916948692 cites W2045771535 @default.
- W2916948692 cites W2047311691 @default.
- W2916948692 cites W2049291124 @default.
- W2916948692 cites W2052082578 @default.
- W2916948692 cites W205336007 @default.
- W2916948692 cites W2056071098 @default.
- W2916948692 cites W2056088071 @default.
- W2916948692 cites W2066049957 @default.
- W2916948692 cites W2066525457 @default.
- W2916948692 cites W2070703107 @default.
- W2916948692 cites W2077434205 @default.
- W2916948692 cites W2082268198 @default.
- W2916948692 cites W2086013207 @default.
- W2916948692 cites W2086943348 @default.
- W2916948692 cites W2089273131 @default.
- W2916948692 cites W2097155839 @default.
- W2916948692 cites W2100693325 @default.
- W2916948692 cites W2102218959 @default.
- W2916948692 cites W2107277218 @default.
- W2916948692 cites W2111897512 @default.
- W2916948692 cites W2115291512 @default.
- W2916948692 cites W2122839622 @default.
- W2916948692 cites W2126871758 @default.
- W2916948692 cites W2128730970 @default.
- W2916948692 cites W2128916925 @default.
- W2916948692 cites W2135302770 @default.
- W2916948692 cites W2148240349 @default.
- W2916948692 cites W2150089550 @default.
- W2916948692 cites W2164706126 @default.
- W2916948692 cites W2195992255 @default.
- W2916948692 cites W2344331792 @default.
- W2916948692 cites W2411779324 @default.
- W2916948692 cites W2580061807 @default.
- W2916948692 cites W2581343857 @default.
- W2916948692 cites W2584931446 @default.
- W2916948692 cites W2740722275 @default.
- W2916948692 cites W2772669508 @default.
- W2916948692 cites W2791532651 @default.
- W2916948692 cites W2807638211 @default.
- W2916948692 cites W4211146134 @default.
- W2916948692 cites W1964184380 @default.
- W2916948692 doi "https://doi.org/10.1038/s41598-019-39370-4" @default.
- W2916948692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6391488" @default.
- W2916948692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30808942" @default.
- W2916948692 hasPublicationYear "2019" @default.
- W2916948692 type Work @default.
- W2916948692 sameAs 2916948692 @default.
- W2916948692 citedByCount "21" @default.
- W2916948692 countsByYear W29169486922019 @default.
- W2916948692 countsByYear W29169486922020 @default.
- W2916948692 countsByYear W29169486922021 @default.
- W2916948692 countsByYear W29169486922022 @default.
- W2916948692 countsByYear W29169486922023 @default.
- W2916948692 crossrefType "journal-article" @default.
- W2916948692 hasAuthorship W2916948692A5000535977 @default.