Matches in SemOpenAlex for { <https://semopenalex.org/work/W2916983800> ?p ?o ?g. }
- W2916983800 abstract "Phosphatidylserine (PS) is PS asymmetry in the eukaryotic cell membrane is maintained by a group of proteins belonging to the P4-ATPase family, namely, PS flippases. The folding and transporting of P4-ATPases to their cellular destination requires a beta-subunit member of the TMEM30 protein family. Loss of Tmem30a has been shown to cause multiple disease conditions. However, its roles in vascular development have not been elucidated. Here, we show that TMEM30A plays critical roles in retinal vascular angiogenesis, which is a fundamental process in vascular development. Our data indicated that knockdown of TMEM30A in primary human retinal endothelial cells led to reduced tube formation. In mice, endothelial cell (EC)-specific deletion of Tmem30a led to retarded retinal vascular development with a hyperpruned vascular network as well as blunted-end, aneurysm-like tip endothelial cells (ECs) with fewer filopodia at the vascular front and reduced number of tip cells. Deletion of Tmem30a also impaired vessel barrier integrity. Mechanistically, deletion of TMEM30A caused reduced EC proliferation by inhibiting VEGF-induced signaling. Our findings reveal essential roles of TMEM30A in angiogenesis, and providing a potential therapeutic target." @default.
- W2916983800 created "2019-03-02" @default.
- W2916983800 creator A5017304177 @default.
- W2916983800 creator A5021080053 @default.
- W2916983800 creator A5021541475 @default.
- W2916983800 creator A5037634210 @default.
- W2916983800 creator A5041122412 @default.
- W2916983800 creator A5056614628 @default.
- W2916983800 creator A5057411027 @default.
- W2916983800 creator A5058440498 @default.
- W2916983800 creator A5068508411 @default.
- W2916983800 date "2019-01-01" @default.
- W2916983800 modified "2023-10-02" @default.
- W2916983800 title "Tmem30a Deficiency in endothelial cells impairs cell proliferation and angiogenesis" @default.
- W2916983800 cites W1573363574 @default.
- W2916983800 cites W1968192565 @default.
- W2916983800 cites W1975689297 @default.
- W2916983800 cites W1985907458 @default.
- W2916983800 cites W1993913999 @default.
- W2916983800 cites W2006542554 @default.
- W2916983800 cites W2009084021 @default.
- W2916983800 cites W2026478676 @default.
- W2916983800 cites W2026776487 @default.
- W2916983800 cites W2027072680 @default.
- W2916983800 cites W2030537668 @default.
- W2916983800 cites W2035992043 @default.
- W2916983800 cites W2042742511 @default.
- W2916983800 cites W2046338633 @default.
- W2916983800 cites W2046525214 @default.
- W2916983800 cites W2049948334 @default.
- W2916983800 cites W2054728198 @default.
- W2916983800 cites W2056451594 @default.
- W2916983800 cites W2060119578 @default.
- W2916983800 cites W2060759428 @default.
- W2916983800 cites W2061539000 @default.
- W2916983800 cites W2072179660 @default.
- W2916983800 cites W2074196937 @default.
- W2916983800 cites W2079181228 @default.
- W2916983800 cites W2091774189 @default.
- W2916983800 cites W2101690661 @default.
- W2916983800 cites W2106901733 @default.
- W2916983800 cites W2114916121 @default.
- W2916983800 cites W2129723413 @default.
- W2916983800 cites W2133529176 @default.
- W2916983800 cites W2137029911 @default.
- W2916983800 cites W2154814963 @default.
- W2916983800 cites W2155955312 @default.
- W2916983800 cites W2179142653 @default.
- W2916983800 cites W2184070211 @default.
- W2916983800 cites W2214704277 @default.
- W2916983800 cites W2289446925 @default.
- W2916983800 cites W2335860304 @default.
- W2916983800 cites W2396069703 @default.
- W2916983800 cites W2524030103 @default.
- W2916983800 cites W2749652970 @default.
- W2916983800 cites W2754044861 @default.
- W2916983800 cites W2767828657 @default.
- W2916983800 cites W2793388835 @default.
- W2916983800 cites W2799436093 @default.
- W2916983800 cites W2800254125 @default.
- W2916983800 cites W2801785887 @default.
- W2916983800 cites W2802403023 @default.
- W2916983800 cites W2802758882 @default.
- W2916983800 cites W2803401792 @default.
- W2916983800 doi "https://doi.org/10.1242/jcs.225052" @default.
- W2916983800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30814335" @default.
- W2916983800 hasPublicationYear "2019" @default.
- W2916983800 type Work @default.
- W2916983800 sameAs 2916983800 @default.
- W2916983800 citedByCount "11" @default.
- W2916983800 countsByYear W29169838002020 @default.
- W2916983800 countsByYear W29169838002021 @default.
- W2916983800 countsByYear W29169838002022 @default.
- W2916983800 countsByYear W29169838002023 @default.
- W2916983800 crossrefType "journal-article" @default.
- W2916983800 hasAuthorship W2916983800A5017304177 @default.
- W2916983800 hasAuthorship W2916983800A5021080053 @default.
- W2916983800 hasAuthorship W2916983800A5021541475 @default.
- W2916983800 hasAuthorship W2916983800A5037634210 @default.
- W2916983800 hasAuthorship W2916983800A5041122412 @default.
- W2916983800 hasAuthorship W2916983800A5056614628 @default.
- W2916983800 hasAuthorship W2916983800A5057411027 @default.
- W2916983800 hasAuthorship W2916983800A5058440498 @default.
- W2916983800 hasAuthorship W2916983800A5068508411 @default.
- W2916983800 hasBestOaLocation W29169838001 @default.
- W2916983800 hasConcept C123012128 @default.
- W2916983800 hasConcept C125705527 @default.
- W2916983800 hasConcept C202751555 @default.
- W2916983800 hasConcept C203014093 @default.
- W2916983800 hasConcept C2780040266 @default.
- W2916983800 hasConcept C2780394083 @default.
- W2916983800 hasConcept C2780827179 @default.
- W2916983800 hasConcept C502942594 @default.
- W2916983800 hasConcept C54355233 @default.
- W2916983800 hasConcept C55493867 @default.
- W2916983800 hasConcept C62112901 @default.
- W2916983800 hasConcept C62478195 @default.
- W2916983800 hasConcept C86803240 @default.
- W2916983800 hasConcept C90301020 @default.
- W2916983800 hasConcept C95444343 @default.