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- W2917004593 abstract "Tracking injected therapeutic agents in either ablation or new immunotherapies is critical to optimizing distribution, preventing complications, and understanding therapeutic effects. In the context of thermochemical ablation (TCA), there is little to no contrast on CT imaging with the most frequently studied salt, sodium acetate, even at high concentrations. However, incorporation of cesium hydroxide as the base in TCA may provide a solution to this problem. Cesium has a favorable toxicity profile and its position on the periodic table near barium and iodine should ensure substantial attenuation of X-ray photons. To investigate this question, it is essential to determine the concentration range at which cesium may be used as a contrast agent. Cesium hydroxide solutions of varying concentrations (0, 3.75, 9.37, 11.24, 18.74, 74.96, 149.91, 224.87 mg/L) were placed within a water phantom and scanned at 120 kVp (Siemens Definition Flash). Images were digitally reconstructed using 3D Slicer. Region of interest maps were made within each solution tube and mean attenuation values in Hounsfield units (HU) were extracted from the reconstructed images. Mean values were then plotted against the concentration of cesium hydroxide to establish the attenuation coefficient for aqueous cesium hydroxide. When scanning at 120 kVp, mean attenuation values ranged from -0.725 to 7.789 HU. Attenuation values plotted against concentration of cesium hydroxide demonstrated an attenuation coefficient of 0.0332 HU (R2=0.9411) per mg/L of cesium hydroxide. As anticipated, cesium hydroxide has clear potential as a contrast agent to aid in imaging of TCA. Based on the attenuation coefficient of 0.0332 HU per mg/L of cesium hydroxide, concentrations on the order of 1500 mg/L will produce nearly 50 HU of attenuation and are sufficient to function as a contrast agent. The low concentration required combined with the favorable toxicity profile suggest that it will function well in future studies involving TCA." @default.
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- W2917004593 date "2019-03-01" @default.
- W2917004593 modified "2023-09-25" @default.
- W2917004593 title "Abstract No. 504 Evaluating utility of cesium for real-time tracking and correlation studies in thermochemical ablation" @default.
- W2917004593 doi "https://doi.org/10.1016/j.jvir.2018.12.585" @default.
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