FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917016288> ?p ?o ?g. }

• W2917016288 endingPage "3052" @default.
• W2917016288 startingPage "3048" @default.
• W2917016288 abstract "Many conventional antidepressants can quickly raise the levels of extracellular serotonin, yet their positive effects on mood ensues only weeks later. This delay in efficacy is a clinical problem that has proven difficult to overcome. Early investigation noted that the initial increases in extracellular serotonin engaged strong feedback inhibition of serotonin neurons via 5-HT1A autoreceptors, resulting in a profound reduction in their firing rate. Over the course of chronic treatment, however, firing rate returned to normal and the inhibition via 5-HT1A receptor agonists was attenuated. The coincident timeline of these phenomena led to the influential hypothesis that the relationship was causal and that gradual loss of feedback inhibition mediated by 5-HT1A receptors was critical to the delayed therapeutic onset. Simple and appealing, the desensitization hypothesis has taken strong hold, yet much of the supporting evidence is circumstantial and there are several observations that would refute a causal relationship. In particular, even though 5-HT1A receptors may desensitize, there is evidence that feedback inhibition mediated by remaining receptors persists. That is, baseline serotonin firing rate returns to normal not because of 5-HT1A desensitization but rather despite ongoing feedback inhibition. Thus, while 5-HT1A receptors remain important for emotional behavior, it may be other slow-adaptive changes triggered by antidepressants that allow for therapeutic effects, such as those involving glutamatergic synaptic plasticity." @default.
• W2917016288 created "2019-03-02" @default.
• W2917016288 creator A5001108063 @default.
• W2917016288 creator A5045802608 @default.
• W2917016288 date "2019-02-26" @default.
• W2917016288 modified "2023-10-10" @default.
• W2917016288 title "Delayed Antidepressant Efficacy and the Desensitization Hypothesis" @default.
• W2917016288 cites W1491233801 @default.
• W2917016288 cites W1821567097 @default.
• W2917016288 cites W1965776451 @default.
• W2917016288 cites W1967669332 @default.
• W2917016288 cites W1975589456 @default.
• W2917016288 cites W1976473444 @default.
• W2917016288 cites W1993513360 @default.
• W2917016288 cites W1994548103 @default.
• W2917016288 cites W1994702289 @default.
• W2917016288 cites W1996694057 @default.
• W2917016288 cites W1998088135 @default.
• W2917016288 cites W1999399598 @default.
• W2917016288 cites W2019939591 @default.
• W2917016288 cites W2023081218 @default.
• W2917016288 cites W2025409764 @default.
• W2917016288 cites W2030571181 @default.
• W2917016288 cites W2034380066 @default.
• W2917016288 cites W2035421865 @default.
• W2917016288 cites W2035467193 @default.
• W2917016288 cites W2036081896 @default.
• W2917016288 cites W2042248547 @default.
• W2917016288 cites W2050087878 @default.
• W2917016288 cites W2059171399 @default.
• W2917016288 cites W2061494582 @default.
• W2917016288 cites W2061823894 @default.
• W2917016288 cites W2064446568 @default.
• W2917016288 cites W2064525038 @default.
• W2917016288 cites W2068662209 @default.
• W2917016288 cites W2070489989 @default.
• W2917016288 cites W2075566185 @default.
• W2917016288 cites W2078061001 @default.
• W2917016288 cites W2079041682 @default.
• W2917016288 cites W2080466336 @default.
• W2917016288 cites W2083659148 @default.
• W2917016288 cites W2089595156 @default.
• W2917016288 cites W2106885532 @default.
• W2917016288 cites W2117635724 @default.
• W2917016288 cites W2117924155 @default.
• W2917016288 cites W2126050517 @default.
• W2917016288 cites W2129140710 @default.
• W2917016288 cites W2130423340 @default.
• W2917016288 cites W2145728616 @default.
• W2917016288 cites W2148239264 @default.
• W2917016288 cites W2148637867 @default.
• W2917016288 cites W2155132989 @default.
• W2917016288 cites W2158455820 @default.
• W2917016288 cites W2158770881 @default.
• W2917016288 cites W2158903813 @default.
• W2917016288 cites W2159016014 @default.
• W2917016288 cites W2161037740 @default.
• W2917016288 cites W2266226083 @default.
• W2917016288 cites W2287169485 @default.
• W2917016288 cites W2394555212 @default.
• W2917016288 cites W2414239689 @default.
• W2917016288 cites W2889052423 @default.
• W2917016288 cites W3072234959 @default.
• W2917016288 doi "https://doi.org/10.1021/acschemneuro.8b00698" @default.
• W2917016288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7340170" @default.
• W2917016288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30807103" @default.
• W2917016288 hasPublicationYear "2019" @default.
• W2917016288 type Work @default.
• W2917016288 sameAs 2917016288 @default.
• W2917016288 citedByCount "15" @default.
• W2917016288 countsByYear W29170162882019 @default.
• W2917016288 countsByYear W29170162882020 @default.
• W2917016288 countsByYear W29170162882021 @default.
• W2917016288 countsByYear W29170162882022 @default.
• W2917016288 countsByYear W29170162882023 @default.
• W2917016288 crossrefType "journal-article" @default.
• W2917016288 hasAuthorship W2917016288A5001108063 @default.
• W2917016288 hasAuthorship W2917016288A5045802608 @default.
• W2917016288 hasBestOaLocation W29170162882 @default.
• W2917016288 hasConcept C126322002 @default.
• W2917016288 hasConcept C15744967 @default.
• W2917016288 hasConcept C169760540 @default.
• W2917016288 hasConcept C170493617 @default.
• W2917016288 hasConcept C2775864247 @default.
• W2917016288 hasConcept C2779177272 @default.
• W2917016288 hasConcept C2779779143 @default.
• W2917016288 hasConcept C2781161787 @default.
• W2917016288 hasConcept C53910766 @default.
• W2917016288 hasConcept C71924100 @default.
• W2917016288 hasConcept C8439214 @default.
• W2917016288 hasConceptScore W2917016288C126322002 @default.
• W2917016288 hasConceptScore W2917016288C15744967 @default.
• W2917016288 hasConceptScore W2917016288C169760540 @default.
• W2917016288 hasConceptScore W2917016288C170493617 @default.
• W2917016288 hasConceptScore W2917016288C2775864247 @default.
• W2917016288 hasConceptScore W2917016288C2779177272 @default.
• W2917016288 hasConceptScore W2917016288C2779779143 @default.
• W2917016288 hasConceptScore W2917016288C2781161787 @default.

• next