FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917083792> ?p ?o ?g. }

• W2917083792 endingPage "711" @default.
• W2917083792 startingPage "696" @default.
• W2917083792 abstract "Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases with known genetic cause provides an opportunity to understand cellular mechanisms also affected in more complex disorders. We recently reported that loss-of-function mutations in the autophagy adaptor protein SQSTM1/p62 lead to a slowly progressive neurodegenerative disease presenting in childhood. To further elucidate the neuronal involvement, we studied the cellular consequences of loss of p62 in a neuroepithelial stem cell (NESC) model and differentiated neurons derived from reprogrammed p62 patient cells or by CRISPR/Cas9-directed gene editing in NESCs. Transcriptomic and proteomic analyses suggest that p62 is essential for neuronal differentiation by controlling the metabolic shift from aerobic glycolysis to oxidative phosphorylation required for neuronal maturation. This shift is blocked by the failure to sufficiently downregulate lactate dehydrogenase expression due to the loss of p62, possibly through impaired Hif-1α downregulation and increased sensitivity to oxidative stress. The findings imply an important role for p62 in neuronal energy metabolism and particularly in the regulation of the shift between glycolysis and oxidative phosphorylation required for normal neurodifferentiation." @default.
• W2917083792 created "2019-03-02" @default.
• W2917083792 creator A5010495204 @default.
• W2917083792 creator A5015506237 @default.
• W2917083792 creator A5021187598 @default.
• W2917083792 creator A5021900383 @default.
• W2917083792 creator A5024887620 @default.
• W2917083792 creator A5036364090 @default.
• W2917083792 creator A5039038348 @default.
• W2917083792 creator A5044661829 @default.
• W2917083792 creator A5046668272 @default.
• W2917083792 creator A5047282117 @default.
• W2917083792 creator A5050031542 @default.
• W2917083792 creator A5074546907 @default.
• W2917083792 creator A5082800617 @default.
• W2917083792 creator A5088504240 @default.
• W2917083792 date "2019-04-01" @default.
• W2917083792 modified "2023-10-15" @default.
• W2917083792 title "SQSTM1/p62-Directed Metabolic Reprogramming Is Essential for Normal Neurodifferentiation" @default.
• W2917083792 cites W1523693806 @default.
• W2917083792 cites W1530158600 @default.
• W2917083792 cites W1832986140 @default.
• W2917083792 cites W1904531393 @default.
• W2917083792 cites W1935974026 @default.
• W2917083792 cites W1966708766 @default.
• W2917083792 cites W1973884972 @default.
• W2917083792 cites W1974124405 @default.
• W2917083792 cites W1983929660 @default.
• W2917083792 cites W1995042437 @default.
• W2917083792 cites W2002061608 @default.
• W2917083792 cites W2005081126 @default.
• W2917083792 cites W2013961803 @default.
• W2917083792 cites W2019364582 @default.
• W2917083792 cites W2022442206 @default.
• W2917083792 cites W2023598683 @default.
• W2917083792 cites W2025872915 @default.
• W2917083792 cites W2034087770 @default.
• W2917083792 cites W2035320411 @default.
• W2917083792 cites W2052623465 @default.
• W2917083792 cites W2057530007 @default.
• W2917083792 cites W2057868734 @default.
• W2917083792 cites W2066401682 @default.
• W2917083792 cites W2068684244 @default.
• W2917083792 cites W2070835061 @default.
• W2917083792 cites W2096047985 @default.
• W2917083792 cites W2098685543 @default.
• W2917083792 cites W2102354517 @default.
• W2917083792 cites W2107996584 @default.
• W2917083792 cites W2113240092 @default.
• W2917083792 cites W2125908939 @default.
• W2917083792 cites W2126934086 @default.
• W2917083792 cites W2149841333 @default.
• W2917083792 cites W2153032620 @default.
• W2917083792 cites W2156178329 @default.
• W2917083792 cites W2162128880 @default.
• W2917083792 cites W2167702280 @default.
• W2917083792 cites W2278345709 @default.
• W2917083792 cites W2279313673 @default.
• W2917083792 cites W2288529957 @default.
• W2917083792 cites W2324264094 @default.
• W2917083792 cites W2408352991 @default.
• W2917083792 cites W2416068580 @default.
• W2917083792 cites W2511569453 @default.
• W2917083792 cites W2589026565 @default.
• W2917083792 cites W2599888581 @default.
• W2917083792 cites W2624475221 @default.
• W2917083792 cites W2766930070 @default.
• W2917083792 cites W2784311670 @default.
• W2917083792 cites W2811109665 @default.
• W2917083792 cites W775311174 @default.
• W2917083792 cites W807920197 @default.
• W2917083792 cites W993193191 @default.
• W2917083792 doi "https://doi.org/10.1016/j.stemcr.2019.01.023" @default.
• W2917083792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6449840" @default.
• W2917083792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30827875" @default.
• W2917083792 hasPublicationYear "2019" @default.
• W2917083792 type Work @default.
• W2917083792 sameAs 2917083792 @default.
• W2917083792 citedByCount "29" @default.
• W2917083792 countsByYear W29170837922019 @default.
• W2917083792 countsByYear W29170837922020 @default.
• W2917083792 countsByYear W29170837922021 @default.
• W2917083792 countsByYear W29170837922022 @default.
• W2917083792 countsByYear W29170837922023 @default.
• W2917083792 crossrefType "journal-article" @default.
• W2917083792 hasAuthorship W2917083792A5010495204 @default.
• W2917083792 hasAuthorship W2917083792A5015506237 @default.
• W2917083792 hasAuthorship W2917083792A5021187598 @default.
• W2917083792 hasAuthorship W2917083792A5021900383 @default.
• W2917083792 hasAuthorship W2917083792A5024887620 @default.
• W2917083792 hasAuthorship W2917083792A5036364090 @default.
• W2917083792 hasAuthorship W2917083792A5039038348 @default.
• W2917083792 hasAuthorship W2917083792A5044661829 @default.
• W2917083792 hasAuthorship W2917083792A5046668272 @default.
• W2917083792 hasAuthorship W2917083792A5047282117 @default.
• W2917083792 hasAuthorship W2917083792A5050031542 @default.
• W2917083792 hasAuthorship W2917083792A5074546907 @default.
• W2917083792 hasAuthorship W2917083792A5082800617 @default.

• next