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• W2917102118 endingPage "245" @default.
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• W2917102118 abstract "The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands, which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich pharmacology and therapeutic potential, it is essential to understand their structure and function thoroughly. This deep characterization was hampered by the lack of experimental structural information for many years. Thus, computational techniques have been extensively combined with experimental data, in order to undertake the study of γ-aminobutyric acid type A receptors and their interaction with drugs. Here, we review the exciting journey made to assess the structures of these receptors and outline major outcomes. Finally, we discuss the brand new structure of the α 1 β 2 γ 2 subtype and the amazing advances it brings to the field." @default.
• W2917102118 created "2019-03-02" @default.
• W2917102118 creator A5016571029 @default.
• W2917102118 creator A5031575323 @default.
• W2917102118 creator A5037491299 @default.
• W2917102118 creator A5038994324 @default.
• W2917102118 date "2019-02-01" @default.
• W2917102118 modified "2023-10-16" @default.
• W2917102118 title "GABA_A receptor family: overview on structural characterization" @default.
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