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• W2917152053 endingPage "e13018" @default.
• W2917152053 startingPage "e13018" @default.
• W2917152053 abstract "One of the hallmarks of the parasitic phylum of Apicomplexa is the presence of highly specialised, apical secretory organelles, called the micronemes and rhoptries that play critical roles in ensuring survival and dissemination. Upon exocytosis, the micronemes release adhesin complexes, perforins, and proteases that are crucially implicated in egress from infected cells, gliding motility, migration across biological barriers, and host cell invasion. Recent studies on Toxoplasma gondii and Plasmodium species have shed more light on the signalling events and the machinery that trigger microneme secretion. Intracellular cyclic nucleotides, calcium level, and phosphatidic acid act as key mediators of microneme exocytosis, and several downstream effectors have been identified. Here, we review the key steps of microneme biogenesis and exocytosis, summarising the still fractal knowledge at the molecular level regarding the fusion event with the parasite plasma membrane." @default.
• W2917152053 created "2019-03-02" @default.
• W2917152053 creator A5002955450 @default.
• W2917152053 creator A5050919940 @default.
• W2917152053 date "2019-03-18" @default.
• W2917152053 modified "2023-10-15" @default.
• W2917152053 title "Biogenesis and secretion of micronemes in<i>Toxoplasma gondii</i>" @default.
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