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• W2917187791 endingPage "100168" @default.
• W2917187791 startingPage "100168" @default.
• W2917187791 abstract "Alcohol misuse often manifests in two different patterns of drinking; Binge Drinking (BD; ≥4 (women) or ≥ 5 (men) drinks/day, ≤12 days/month) or Heavy Drinking (HD; ≥3 (women) or ≥4 (men) drinks/day, ≥16 days/month). Although direct comparisons have not been made, structural MRI studies indicate that the two types of drinking behaviors might be associated with different neuromorphometric characteristics.This study used a cross-sectional design to compare brain structure (using MRI derived subcortical volume and cortical thickness measures) between participants with histories of BD (N = 16), HD (N = 15), and Healthy Controls (HC; N = 21). Whole-brain analyses were used to quantify group differences in subcortical volume and cortical thickness. Resulting cortical thickness clusters were quantified for their areas of overlap with resting-state network parcellations.BD was associated with decreased volumes of the bilateral global pallidus and decreased cortical thickness within the left superior-parietal cluster (p < .05). This cortical cluster overlapped in surface area with the dorsal-attention (50.86%) and the fronto-parietal network parcellations (49.14%). HD was associated with increased cortical thickness in the left medial occipito-parietal cluster (p < .05). This cluster primarily overlapped with the visual network parcellation (89%) and, to a lesser extent, with a widespread number of network parcellations (dorsal-attention: 3.8%; fronto-parietal: 3.5%; default-mode: 3.2%).These data indicate that histories of BD and HD patterns are associated with distinct neuromorphometric characteristics. BD was associated with changes within the executive control networks and the globus pallidus. HD was associated with widespread changes, that are primarily localized within the visual network." @default.
• W2917187791 created "2019-03-02" @default.
• W2917187791 creator A5017073162 @default.
• W2917187791 creator A5035326010 @default.
• W2917187791 creator A5077232072 @default.
• W2917187791 creator A5078299199 @default.
• W2917187791 date "2019-06-01" @default.
• W2917187791 modified "2023-09-30" @default.
• W2917187791 title "A structural MRI study of differential neuromorphometric characteristics of binge and heavy drinking" @default.
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• W2917187791 doi "https://doi.org/10.1016/j.abrep.2019.100168" @default.
• W2917187791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6542838" @default.
• W2917187791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31193798" @default.

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