Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917201807> ?p ?o ?g. }
- W2917201807 endingPage "926" @default.
- W2917201807 startingPage "926" @default.
- W2917201807 abstract "Inefficient removal of dying retinal pigment epithelial (RPE) cells by professional phagocytes can result in debris formation and development of age-related macular degeneration (AMD). Chronic oxidative stress and inflammation play an important role in AMD pathogenesis. Only a few well-established in vitro phagocytosis assay models exist. We propose human embryonic stem cell-derived-RPE cells as a new model for studying RPE cell removal by professional phagocytes. The characteristics of human embryonic stem cells-derived RPE (hESC-RPE) are similar to native RPEs based on their gene and protein expression profile, integrity, and barrier properties or regarding drug transport. However, no data exist about RPE death modalities and how efficiently dying hESC-RPEs are taken upby macrophages, and whether this process triggers an inflammatory responses. This study demonstrates hESC-RPEs can be induced to undergo anoikis or autophagy-associated cell death due to extracellular matrix detachment or serum deprivation and hydrogen-peroxide co-treatment, respectively, similar to primary human RPEs. Dying hESC-RPEs are efficiently engulfed by macrophages which results in high amounts of IL-6 and IL-8 cytokine release. These findings suggest that the clearance of anoikic and autophagy-associated dying hESC-RPEs can be used as a new model for investigating AMD pathogenesis or for testing the in vivo potential of these cells in stem cell therapy." @default.
- W2917201807 created "2019-03-02" @default.
- W2917201807 creator A5001861724 @default.
- W2917201807 creator A5014742619 @default.
- W2917201807 creator A5021448617 @default.
- W2917201807 creator A5022003188 @default.
- W2917201807 creator A5032776608 @default.
- W2917201807 creator A5049282261 @default.
- W2917201807 creator A5050239628 @default.
- W2917201807 creator A5058247214 @default.
- W2917201807 creator A5071846201 @default.
- W2917201807 creator A5091056693 @default.
- W2917201807 creator A5050868844 @default.
- W2917201807 date "2019-02-20" @default.
- W2917201807 modified "2023-10-16" @default.
- W2917201807 title "Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium-Role in Dead Cell Clearance and Inflammation" @default.
- W2917201807 cites W1486743716 @default.
- W2917201807 cites W1493024525 @default.
- W2917201807 cites W1523693806 @default.
- W2917201807 cites W1548614387 @default.
- W2917201807 cites W1560977824 @default.
- W2917201807 cites W1568827127 @default.
- W2917201807 cites W1658577344 @default.
- W2917201807 cites W1658591617 @default.
- W2917201807 cites W1782545213 @default.
- W2917201807 cites W1871390418 @default.
- W2917201807 cites W1891667186 @default.
- W2917201807 cites W1891894356 @default.
- W2917201807 cites W1965789859 @default.
- W2917201807 cites W1966300591 @default.
- W2917201807 cites W1966763839 @default.
- W2917201807 cites W1967267087 @default.
- W2917201807 cites W1967512195 @default.
- W2917201807 cites W1970101659 @default.
- W2917201807 cites W1970528463 @default.
- W2917201807 cites W1977234647 @default.
- W2917201807 cites W1977422420 @default.
- W2917201807 cites W1979129905 @default.
- W2917201807 cites W1979952218 @default.
- W2917201807 cites W1981932438 @default.
- W2917201807 cites W1983230302 @default.
- W2917201807 cites W1984079661 @default.
- W2917201807 cites W1985271970 @default.
- W2917201807 cites W1986660786 @default.
- W2917201807 cites W1987526360 @default.
- W2917201807 cites W1991756308 @default.
- W2917201807 cites W1997480136 @default.
- W2917201807 cites W1998108152 @default.
- W2917201807 cites W1998356393 @default.
- W2917201807 cites W2000314257 @default.
- W2917201807 cites W2000671659 @default.
- W2917201807 cites W2003248626 @default.
- W2917201807 cites W2005487633 @default.
- W2917201807 cites W2006166897 @default.
- W2917201807 cites W2009600776 @default.
- W2917201807 cites W2014007498 @default.
- W2917201807 cites W2015605194 @default.
- W2917201807 cites W2018719587 @default.
- W2917201807 cites W2021814263 @default.
- W2917201807 cites W2025695096 @default.
- W2917201807 cites W2028532536 @default.
- W2917201807 cites W2029152523 @default.
- W2917201807 cites W2030864103 @default.
- W2917201807 cites W2041102525 @default.
- W2917201807 cites W2041995080 @default.
- W2917201807 cites W2043873545 @default.
- W2917201807 cites W2045048112 @default.
- W2917201807 cites W2048030072 @default.
- W2917201807 cites W2052101686 @default.
- W2917201807 cites W2062460463 @default.
- W2917201807 cites W2064334839 @default.
- W2917201807 cites W2064963302 @default.
- W2917201807 cites W2070331057 @default.
- W2917201807 cites W2071709107 @default.
- W2917201807 cites W2074502503 @default.
- W2917201807 cites W2077302000 @default.
- W2917201807 cites W2078532650 @default.
- W2917201807 cites W2079089785 @default.
- W2917201807 cites W2088657362 @default.
- W2917201807 cites W2088847369 @default.
- W2917201807 cites W2091315047 @default.
- W2917201807 cites W2091493364 @default.
- W2917201807 cites W2092045059 @default.
- W2917201807 cites W2092090014 @default.
- W2917201807 cites W2092167465 @default.
- W2917201807 cites W2092638574 @default.
- W2917201807 cites W2095537212 @default.
- W2917201807 cites W2109034822 @default.
- W2917201807 cites W2110056576 @default.
- W2917201807 cites W2110797622 @default.
- W2917201807 cites W2110818336 @default.
- W2917201807 cites W2111274886 @default.
- W2917201807 cites W2114206805 @default.
- W2917201807 cites W2115708356 @default.
- W2917201807 cites W2115742671 @default.
- W2917201807 cites W2117790555 @default.
- W2917201807 cites W2117917811 @default.
- W2917201807 cites W2124789204 @default.