FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917235619> ?p ?o ?g. }

• W2917235619 endingPage "1583" @default.
• W2917235619 startingPage "1576" @default.
• W2917235619 abstract "Congenital bilateral absence of vas deferens (CBAVD) is a special entity in obstructive azoospermia. Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are involved in Taiwanese CBAVD but most heterozygous 5T variant. The solute carrier family 9 isoform 3 (SLC9A3) is the Na+/H+ exchanger, which interacts with CFTR and regulates the Ca2+ homeostasis. Loss of SLC9A3 decreases CFTR protein and causes obstructive azoospermia in mice. It also causes mal-reabsorption by the efferent tubules, which leads to the obstructive phenomenon and eventually results in testicular atrophy. In 6-month old SLC9A3 deficiency mice, the atrophy of their vas deferens and seminal vesicles become more prominent. Decreases of CFTR expression in the reproductive organ in the SLC9A3 deficient (-/-) mice prove the interaction between CFTR and SLC9A3 in the reproductive tract. Most of Taiwanese CBAVD have at least one variant of SLC9A3 deletion and CFTR IVS8-5T, which co-contribute to Taiwanese CBAVD. The report indicates SLC9A3 deficiency can reverse the pathological changes in the gastrointestinal tract of CF mice. Further research can explore the definite mechanism of SLC9A3 and its role interacting with CFTR in different organ systems, which can contribute to novel treatment for the patients with cystic fibrosis and CBAVD." @default.
• W2917235619 created "2019-03-02" @default.
• W2917235619 creator A5001497797 @default.
• W2917235619 creator A5045248168 @default.
• W2917235619 creator A5045910682 @default.
• W2917235619 creator A5050466653 @default.
• W2917235619 date "2019-12-01" @default.
• W2917235619 modified "2023-09-24" @default.
• W2917235619 title "The role of SLC9A3 in Taiwanese patients with congenital bilateral absence of vas deferens (CBAVD)" @default.
• W2917235619 cites W1589657989 @default.
• W2917235619 cites W1968536068 @default.
• W2917235619 cites W1980287917 @default.
• W2917235619 cites W1989519336 @default.
• W2917235619 cites W1994574945 @default.
• W2917235619 cites W2017920989 @default.
• W2917235619 cites W2019401224 @default.
• W2917235619 cites W2022941489 @default.
• W2917235619 cites W2066450974 @default.
• W2917235619 cites W2068816652 @default.
• W2917235619 cites W2080573288 @default.
• W2917235619 cites W2088063696 @default.
• W2917235619 cites W2096374709 @default.
• W2917235619 cites W2123201599 @default.
• W2917235619 cites W2123949450 @default.
• W2917235619 cites W2126391420 @default.
• W2917235619 cites W2126609769 @default.
• W2917235619 cites W2144302045 @default.
• W2917235619 cites W2399234860 @default.
• W2917235619 cites W2605248062 @default.
• W2917235619 cites W2738172705 @default.
• W2917235619 cites W2777296293 @default.
• W2917235619 cites W99577153 @default.
• W2917235619 doi "https://doi.org/10.1016/j.jfma.2019.01.019" @default.
• W2917235619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30797621" @default.
• W2917235619 hasPublicationYear "2019" @default.
• W2917235619 type Work @default.
• W2917235619 sameAs 2917235619 @default.
• W2917235619 citedByCount "6" @default.
• W2917235619 countsByYear W29172356192020 @default.
• W2917235619 countsByYear W29172356192021 @default.
• W2917235619 countsByYear W29172356192022 @default.
• W2917235619 crossrefType "journal-article" @default.
• W2917235619 hasAuthorship W2917235619A5001497797 @default.
• W2917235619 hasAuthorship W2917235619A5045248168 @default.
• W2917235619 hasAuthorship W2917235619A5045910682 @default.
• W2917235619 hasAuthorship W2917235619A5050466653 @default.
• W2917235619 hasBestOaLocation W29172356191 @default.
• W2917235619 hasConcept C121608353 @default.
• W2917235619 hasConcept C126322002 @default.
• W2917235619 hasConcept C134018914 @default.
• W2917235619 hasConcept C16685009 @default.
• W2917235619 hasConcept C2776235491 @default.
• W2917235619 hasConcept C2776938444 @default.
• W2917235619 hasConcept C2777420699 @default.
• W2917235619 hasConcept C2777688143 @default.
• W2917235619 hasConcept C2778210472 @default.
• W2917235619 hasConcept C2778428886 @default.
• W2917235619 hasConcept C2779234561 @default.
• W2917235619 hasConcept C2781087480 @default.
• W2917235619 hasConcept C2781171107 @default.
• W2917235619 hasConcept C2781172350 @default.
• W2917235619 hasConcept C2781254305 @default.
• W2917235619 hasConcept C3018711027 @default.
• W2917235619 hasConcept C54355233 @default.
• W2917235619 hasConcept C71924100 @default.
• W2917235619 hasConcept C86803240 @default.
• W2917235619 hasConceptScore W2917235619C121608353 @default.
• W2917235619 hasConceptScore W2917235619C126322002 @default.
• W2917235619 hasConceptScore W2917235619C134018914 @default.
• W2917235619 hasConceptScore W2917235619C16685009 @default.
• W2917235619 hasConceptScore W2917235619C2776235491 @default.
• W2917235619 hasConceptScore W2917235619C2776938444 @default.
• W2917235619 hasConceptScore W2917235619C2777420699 @default.
• W2917235619 hasConceptScore W2917235619C2777688143 @default.
• W2917235619 hasConceptScore W2917235619C2778210472 @default.
• W2917235619 hasConceptScore W2917235619C2778428886 @default.
• W2917235619 hasConceptScore W2917235619C2779234561 @default.
• W2917235619 hasConceptScore W2917235619C2781087480 @default.
• W2917235619 hasConceptScore W2917235619C2781171107 @default.
• W2917235619 hasConceptScore W2917235619C2781172350 @default.
• W2917235619 hasConceptScore W2917235619C2781254305 @default.
• W2917235619 hasConceptScore W2917235619C3018711027 @default.
• W2917235619 hasConceptScore W2917235619C54355233 @default.
• W2917235619 hasConceptScore W2917235619C71924100 @default.
• W2917235619 hasConceptScore W2917235619C86803240 @default.
• W2917235619 hasIssue "12" @default.
• W2917235619 hasLocation W29172356191 @default.
• W2917235619 hasLocation W29172356192 @default.
• W2917235619 hasLocation W29172356193 @default.
• W2917235619 hasOpenAccess W2917235619 @default.
• W2917235619 hasPrimaryLocation W29172356191 @default.
• W2917235619 hasRelatedWork W180187699 @default.
• W2917235619 hasRelatedWork W1888293540 @default.
• W2917235619 hasRelatedWork W2274358338 @default.
• W2917235619 hasRelatedWork W2354790473 @default.
• W2917235619 hasRelatedWork W2365590532 @default.
• W2917235619 hasRelatedWork W2427919184 @default.
• W2917235619 hasRelatedWork W2605248062 @default.

• next