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• W2917244540 startingPage "10472" @default.
• W2917244540 abstract "Functional codelivery of plasmid DNA and RNA oligonucleotides in the same nanoparticle system is challenging due to differences in their physical properties as well as their intracellular locations of function. In this study, we synthesized a series of reducible branched ester-amine quadpolymers (rBEAQs) and investigated their ability to coencapsulate and deliver DNA plasmids and RNA oligos. The rBEAQs are designed to leverage polymer branching, reducibility, and hydrophobicity to successfully cocomplex DNA and RNA in nanoparticles at low polymer to nucleic acid w/w ratios and enable high delivery efficiency. We validate the synthesis of this new class of biodegradable polymers, characterize the self-assembled nanoparticles that these polymers form with diverse nucleic acids, and demonstrate that the nanoparticles enable safe, effective, and efficient DNA–siRNA codelivery as well as nonviral CRISPR-mediated gene editing utilizing Cas9 DNA and sgRNA codelivery." @default.
• W2917244540 created "2019-03-02" @default.
• W2917244540 creator A5001876568 @default.
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• W2917244540 date "2019-02-22" @default.
• W2917244540 modified "2023-10-14" @default.
• W2917244540 title "Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing" @default.
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• W2917244540 doi "https://doi.org/10.1021/acsami.8b20206" @default.
• W2917244540 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7309334" @default.
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• W2917244540 hasPublicationYear "2019" @default.
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