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- W2917266686 endingPage "1805697" @default.
- W2917266686 startingPage "1805697" @default.
- W2917266686 abstract "As an essential component of immunotherapy, monoclonal antibodies (mAbs) have emerged as a class of powerful therapeutics for treatment of a broad range of diseases. For central nervous system (CNS) diseases, however, the efficacy remains limited due to their inability to enter the CNS. A platform technology is reported here that enables effective delivery of mAbs to the CNS for brain tumor therapy. This is achieved by encapsulating the mAbs within nanocapsules that contain choline and acetylcholine analogues; such analogues facilitate the penetration of the nanocapsules through the brain-blood barrier and the delivery of mAbs to tumor sites. This platform technology uncages the therapeutic power of mAbs for various CNS diseases that remain poorly treated." @default.
- W2917266686 created "2019-03-02" @default.
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- W2917266686 date "2019-02-17" @default.
- W2917266686 modified "2023-10-12" @default.
- W2917266686 title "Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy" @default.
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- W2917266686 doi "https://doi.org/10.1002/adma.201805697" @default.
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