Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917304077> ?p ?o ?g. }
- W2917304077 abstract "Anaplastic Lymphoma Kinase (ALK) which belongs to the Receptor Tyrosine Kinases (RTKs) play a critical role in development and progression of many type of cancers. To design new treatments for ALK associated human diseases, it is essential to study the interactions of the protein to better understand the biological significance of its protein-protein interactions (PPIs) and how they contribute to ALK regulation and function. Novel high-throughput technology, the Mammalian Membrane Two-Hybrid (MaMTH), was used in this study to generate a targeted protein-protein interaction map (interactome) of full length ALK. Biased screening of 150 predicted and previously known ALK interactors were performed and 34 identified as novel ALK interactors. The active mutant cells stably expressing ALK F1245C, F1245I and L1196M have been generated which showed more phosphorylation of ALK (pALK1604) as compared to wild type. Moreover, these active mutants exhibited more phosphorylation of downstream signaling ERK1/2 as compared to wild type.%%%%M.Sc." @default.
- W2917304077 created "2019-03-02" @default.
- W2917304077 creator A5082304370 @default.
- W2917304077 date "2018-06-01" @default.
- W2917304077 modified "2023-09-27" @default.
- W2917304077 title "Mapping and Characterization of the Interaction Network of ALK Receptor Tyrosine Kinase using the Mammalian Membrane Two-Hybrid (MaMTH) Assay" @default.
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