Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917312928> ?p ?o ?g. }
- W2917312928 abstract "Microtubule-associated protein tau (MAPT) is essential for the assembly and stability of microtubule and the functional maintenance of the nervous system. Tau is abundant in neurons and detectable in astrocytes and oligodendrocytes. However, whether tau existed in Schwann cells, the unique glial cells in the peripheral nervous system, remains unclear. Here, we investigated the presence of tau and its coding gene MAPT in cultured Schwann cells and found the presence of tau. The gene-silencing of MAPT promoted Schwann cell proliferation and inhibited Schwann cell migration and differentiation. In vivo application of MAPT siRNA suppressed the migration of Schwann cells after sciatic nerve injury. Consistently, tau knockout mice showed elevated proliferation and reduced migration of Schwann cells. Rats injected with MAPT siRNA and tau knockout mice also exhibited impaired myelin and lipid debris clearance. The expressions and distributions of cytoskeleton proteins α-Tubulin and F-actin were disrupted as well. These findings demonstrated the existence and biological effects of tau on Schwann cells and expanded our understanding of the function of tau in the nervous system." @default.
- W2917312928 created "2019-03-02" @default.
- W2917312928 creator A5002166365 @default.
- W2917312928 creator A5012879821 @default.
- W2917312928 creator A5018804020 @default.
- W2917312928 creator A5038683970 @default.
- W2917312928 creator A5039567363 @default.
- W2917312928 creator A5059016839 @default.
- W2917312928 creator A5068254443 @default.
- W2917312928 creator A5069612314 @default.
- W2917312928 creator A5083708010 @default.
- W2917312928 creator A5086371835 @default.
- W2917312928 creator A5088536927 @default.
- W2917312928 date "2019-01-01" @default.
- W2917312928 modified "2023-09-29" @default.
- W2917312928 title "Tau modulated Schwann cell proliferation, migration, and differentiation following peripheral nerve injury" @default.
- W2917312928 cites W1803223003 @default.
- W2917312928 cites W1897859562 @default.
- W2917312928 cites W1965932992 @default.
- W2917312928 cites W1971165215 @default.
- W2917312928 cites W1993291573 @default.
- W2917312928 cites W1994234870 @default.
- W2917312928 cites W1995405296 @default.
- W2917312928 cites W1995717532 @default.
- W2917312928 cites W2003791049 @default.
- W2917312928 cites W2005067021 @default.
- W2917312928 cites W2034710096 @default.
- W2917312928 cites W2084989810 @default.
- W2917312928 cites W2087620664 @default.
- W2917312928 cites W2138046729 @default.
- W2917312928 cites W2142980305 @default.
- W2917312928 cites W2169503014 @default.
- W2917312928 cites W2181106802 @default.
- W2917312928 cites W2189553045 @default.
- W2917312928 cites W2232424546 @default.
- W2917312928 cites W2299800011 @default.
- W2917312928 cites W2329296251 @default.
- W2917312928 cites W2333578786 @default.
- W2917312928 cites W2396814975 @default.
- W2917312928 cites W2417251365 @default.
- W2917312928 cites W2468489993 @default.
- W2917312928 cites W2524717417 @default.
- W2917312928 cites W2754540456 @default.
- W2917312928 cites W2762378928 @default.
- W2917312928 cites W2770793072 @default.
- W2917312928 cites W2789008687 @default.
- W2917312928 cites W4213263913 @default.
- W2917312928 cites W2464389379 @default.
- W2917312928 doi "https://doi.org/10.1242/jcs.222059" @default.
- W2917312928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30782778" @default.
- W2917312928 hasPublicationYear "2019" @default.
- W2917312928 type Work @default.
- W2917312928 sameAs 2917312928 @default.
- W2917312928 citedByCount "28" @default.
- W2917312928 countsByYear W29173129282020 @default.
- W2917312928 countsByYear W29173129282021 @default.
- W2917312928 countsByYear W29173129282022 @default.
- W2917312928 countsByYear W29173129282023 @default.
- W2917312928 crossrefType "journal-article" @default.
- W2917312928 hasAuthorship W2917312928A5002166365 @default.
- W2917312928 hasAuthorship W2917312928A5012879821 @default.
- W2917312928 hasAuthorship W2917312928A5018804020 @default.
- W2917312928 hasAuthorship W2917312928A5038683970 @default.
- W2917312928 hasAuthorship W2917312928A5039567363 @default.
- W2917312928 hasAuthorship W2917312928A5059016839 @default.
- W2917312928 hasAuthorship W2917312928A5068254443 @default.
- W2917312928 hasAuthorship W2917312928A5069612314 @default.
- W2917312928 hasAuthorship W2917312928A5083708010 @default.
- W2917312928 hasAuthorship W2917312928A5086371835 @default.
- W2917312928 hasAuthorship W2917312928A5088536927 @default.
- W2917312928 hasBestOaLocation W29173129281 @default.
- W2917312928 hasConcept C104317684 @default.
- W2917312928 hasConcept C105702510 @default.
- W2917312928 hasConcept C113246987 @default.
- W2917312928 hasConcept C119056186 @default.
- W2917312928 hasConcept C142669718 @default.
- W2917312928 hasConcept C1491633281 @default.
- W2917312928 hasConcept C169760540 @default.
- W2917312928 hasConcept C202751555 @default.
- W2917312928 hasConcept C20418707 @default.
- W2917312928 hasConcept C2777004073 @default.
- W2917312928 hasConcept C2778609137 @default.
- W2917312928 hasConcept C2781149210 @default.
- W2917312928 hasConcept C529278444 @default.
- W2917312928 hasConcept C54355233 @default.
- W2917312928 hasConcept C545314008 @default.
- W2917312928 hasConcept C545706735 @default.
- W2917312928 hasConcept C86803240 @default.
- W2917312928 hasConcept C95444343 @default.
- W2917312928 hasConceptScore W2917312928C104317684 @default.
- W2917312928 hasConceptScore W2917312928C105702510 @default.
- W2917312928 hasConceptScore W2917312928C113246987 @default.
- W2917312928 hasConceptScore W2917312928C119056186 @default.
- W2917312928 hasConceptScore W2917312928C142669718 @default.
- W2917312928 hasConceptScore W2917312928C1491633281 @default.
- W2917312928 hasConceptScore W2917312928C169760540 @default.
- W2917312928 hasConceptScore W2917312928C202751555 @default.
- W2917312928 hasConceptScore W2917312928C20418707 @default.
- W2917312928 hasConceptScore W2917312928C2777004073 @default.
- W2917312928 hasConceptScore W2917312928C2778609137 @default.