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- W2917366413 abstract "Matriptase is ectopically expressed in neoplastic B-cells, in which matriptase activity is enhanced by negligible expression of its endogenous inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. HAI-1, however, is also involved in matriptase synthesis and intracellular trafficking. The lack of HAI-1 indicates that other related inhibitor, such as HAI-2, might be expressed. Here, we show that HAI-2 is commonly co-expressed in matriptase-expressing neoplastic B-cells. The level of active matriptase shed after induction of matriptase zymogen activation in 7 different neoplastic B-cells was next determined and characterised. Our data reveal that active matriptase can only be generated and shed by those cells able to activate matriptase and in a rough correlation with the levels of matriptase protein. While HAI-2 can potently inhibit matriptase, the levels of active matriptase are not proportionally suppressed in those cells with high HAI-2. Our survey suggests that matriptase proteolysis might aberrantly remain high in neoplastic B-cells regardless of the levels of HAI-2." @default.
- W2917366413 created "2019-03-02" @default.
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- W2917366413 date "2019-01-01" @default.
- W2917366413 modified "2023-10-16" @default.
- W2917366413 title "Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2" @default.
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- W2917366413 doi "https://doi.org/10.1080/14756366.2019.1577831" @default.
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