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- W2917366865 abstract "During mitosis, motor proteins associate with microtubules to exert pushing forces that establish a mitotic spindle. These pushing forces generate opposing tension in the chromatin that connects oppositely attached sister chromatids, which may then act as a mechanical signal to ensure the fidelity of chromosome segregation during mitosis. However, the role of tension in mitotic cellular signaling remains controversial. In this study, we generated a gradient in tension over multiple isogenic budding yeast cell lines by genetically altering the magnitude of motor-based spindle forces. We found that a decreasing gradient in tension led to an increasing gradient in the rates of kinetochore detachment and anaphase chromosome mis-segregration, and in metaphase time. Simulations and experiments indicated that these tension responses originate from a tension-dependent kinetochore phosphorylation gradient. We conclude that the cell is exquisitely tuned to the magnitude of tension as a signal to detect potential chromosome segregation errors during mitosis." @default.
- W2917366865 created "2019-03-02" @default.
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- W2917366865 date "2019-04-01" @default.
- W2917366865 modified "2023-09-25" @default.
- W2917366865 title "A Gradient in Metaphase Tension Leads to a Scaled Cellular Response in Mitosis" @default.
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- W2917366865 doi "https://doi.org/10.1016/j.devcel.2019.01.018" @default.
- W2917366865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6535804" @default.
- W2917366865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30799228" @default.
- W2917366865 hasPublicationYear "2019" @default.
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