FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917369637> ?p ?o ?g. }

• W2917369637 abstract "Abstract The prion protein (PrP) misfolds and assembles into a wide spectrum of self-propagating quaternary structures, designated PrP Sc . These various PrP superstructures can be functionally different, conferring clinically distinctive symptomatology, neuropathology and infectious character to the associated prion diseases. However, a satisfying molecular basis of PrP structural diversity is lacking in the literature. To provide mechanistic insights into the etiology of PrP polymorphism, we have engineered a set of 6 variants of the human protein and obtained PrP amyloid fibrils. We show that pressure induces dissociation of the fibrils, albeit with different kinetics. In addition, by focusing on the generic properties of amyloid fibrils, such as the thioflavin T binding capacities and the PK-resistance, we reveal an unprecedented structure-barostability phenomenological relationship. We propose that the structural diversity of PrP fibrils encompass a multiplicity of packing defects (water-excluded cavities) in their hydrophobic cores, and that the resultant sensitivity to pressure should be considered as a general molecular criterion to accurately define fibril morphotypes. We anticipate that our insights into sequence-dependent fibrillation and conformational stability will shed light on the highly-nuanced prion strain phenomenon and open the opportunity to explain different PrP conformations in terms of volumetric physics." @default.
• W2917369637 created "2019-03-02" @default.
• W2917369637 creator A5002753836 @default.
• W2917369637 creator A5009847205 @default.
• W2917369637 creator A5014484178 @default.
• W2917369637 creator A5024319982 @default.
• W2917369637 creator A5044888311 @default.
• W2917369637 creator A5077610810 @default.
• W2917369637 creator A5079497279 @default.
• W2917369637 creator A5084749850 @default.
• W2917369637 date "2019-02-26" @default.
• W2917369637 modified "2023-10-08" @default.
• W2917369637 title "Pressure Reveals Unique Conformational Features in Prion Protein Fibril Diversity" @default.
• W2917369637 cites W1759554373 @default.
• W2917369637 cites W1964944526 @default.
• W2917369637 cites W1974497193 @default.
• W2917369637 cites W1985686491 @default.
• W2917369637 cites W1989150559 @default.
• W2917369637 cites W1989808640 @default.
• W2917369637 cites W1993637257 @default.
• W2917369637 cites W1999180861 @default.
• W2917369637 cites W2003020823 @default.
• W2917369637 cites W2009604591 @default.
• W2917369637 cites W2013679718 @default.
• W2917369637 cites W2019521349 @default.
• W2917369637 cites W2023795976 @default.
• W2917369637 cites W2026332642 @default.
• W2917369637 cites W2037757964 @default.
• W2917369637 cites W2040375783 @default.
• W2917369637 cites W2050005958 @default.
• W2917369637 cites W2054445727 @default.
• W2917369637 cites W2059804089 @default.
• W2917369637 cites W2062102053 @default.
• W2917369637 cites W2063826033 @default.
• W2917369637 cites W2063827082 @default.
• W2917369637 cites W2068476414 @default.
• W2917369637 cites W2069951134 @default.
• W2917369637 cites W2072413573 @default.
• W2917369637 cites W2076834744 @default.
• W2917369637 cites W2089215677 @default.
• W2917369637 cites W2118966800 @default.
• W2917369637 cites W2119152368 @default.
• W2917369637 cites W2125600555 @default.
• W2917369637 cites W2141250779 @default.
• W2917369637 cites W2144166008 @default.
• W2917369637 cites W2164513199 @default.
• W2917369637 cites W2329747753 @default.
• W2917369637 cites W2347181525 @default.
• W2917369637 cites W2395421773 @default.
• W2917369637 cites W2408079270 @default.
• W2917369637 cites W2472688469 @default.
• W2917369637 cites W2582755318 @default.
• W2917369637 cites W2606345593 @default.
• W2917369637 cites W2760359433 @default.
• W2917369637 doi "https://doi.org/10.1038/s41598-019-39261-8" @default.
• W2917369637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6391531" @default.
• W2917369637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30808892" @default.
• W2917369637 hasPublicationYear "2019" @default.
• W2917369637 type Work @default.
• W2917369637 sameAs 2917369637 @default.
• W2917369637 citedByCount "9" @default.
• W2917369637 countsByYear W29173696372021 @default.
• W2917369637 countsByYear W29173696372022 @default.
• W2917369637 countsByYear W29173696372023 @default.
• W2917369637 crossrefType "journal-article" @default.
• W2917369637 hasAuthorship W2917369637A5002753836 @default.
• W2917369637 hasAuthorship W2917369637A5009847205 @default.
• W2917369637 hasAuthorship W2917369637A5014484178 @default.
• W2917369637 hasAuthorship W2917369637A5024319982 @default.
• W2917369637 hasAuthorship W2917369637A5044888311 @default.
• W2917369637 hasAuthorship W2917369637A5077610810 @default.
• W2917369637 hasAuthorship W2917369637A5079497279 @default.
• W2917369637 hasAuthorship W2917369637A5084749850 @default.
• W2917369637 hasBestOaLocation W29173696371 @default.
• W2917369637 hasConcept C12554922 @default.
• W2917369637 hasConcept C142724271 @default.
• W2917369637 hasConcept C147597530 @default.
• W2917369637 hasConcept C185592680 @default.
• W2917369637 hasConcept C27523624 @default.
• W2917369637 hasConcept C2778896982 @default.
• W2917369637 hasConcept C2779134260 @default.
• W2917369637 hasConcept C2994168385 @default.
• W2917369637 hasConcept C3019447875 @default.
• W2917369637 hasConcept C3019804061 @default.
• W2917369637 hasConcept C47701112 @default.
• W2917369637 hasConcept C502032728 @default.
• W2917369637 hasConcept C55493867 @default.
• W2917369637 hasConcept C59593255 @default.
• W2917369637 hasConcept C70721500 @default.
• W2917369637 hasConcept C71924100 @default.
• W2917369637 hasConcept C86803240 @default.
• W2917369637 hasConceptScore W2917369637C12554922 @default.
• W2917369637 hasConceptScore W2917369637C142724271 @default.
• W2917369637 hasConceptScore W2917369637C147597530 @default.
• W2917369637 hasConceptScore W2917369637C185592680 @default.
• W2917369637 hasConceptScore W2917369637C27523624 @default.
• W2917369637 hasConceptScore W2917369637C2778896982 @default.
• W2917369637 hasConceptScore W2917369637C2779134260 @default.
• W2917369637 hasConceptScore W2917369637C2994168385 @default.
• W2917369637 hasConceptScore W2917369637C3019447875 @default.

• next