FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917369987> ?p ?o ?g. }

• W2917369987 abstract "Chemically modified mRNA is an efficient, biocompatible modality for therapeutic protein expression. We report a first-time-in-human study of this modality, aiming to evaluate safety and potential therapeutic effects. Men with type 2 diabetes mellitus (T2DM) received intradermal injections of modified mRNA encoding vascular endothelial growth factor A (VEGF-A) or buffered saline placebo (ethical obligations precluded use of a non-translatable mRNA control) at randomized sites on the forearm. The only causally treatment-related adverse events were mild injection-site reactions. Skin microdialysis revealed elevated VEGF-A protein levels at mRNA-treated sites versus placebo-treated sites from about 4-24 hours post-administration. Enhancements in basal skin blood flow at 4 hours and 7 days post-administration were detected using laser Doppler fluximetry and imaging. Intradermal VEGF-A mRNA was well tolerated and led to local functional VEGF-A protein expression and transient skin blood flow enhancement in men with T2DM. VEGF-A mRNA may have therapeutic potential for regenerative angiogenesis." @default.
• W2917369987 created "2019-03-02" @default.
• W2917369987 creator A5012722902 @default.
• W2917369987 creator A5024667775 @default.
• W2917369987 creator A5029540294 @default.
• W2917369987 creator A5031918109 @default.
• W2917369987 creator A5036204802 @default.
• W2917369987 creator A5037085522 @default.
• W2917369987 creator A5037371315 @default.
• W2917369987 creator A5039027696 @default.
• W2917369987 creator A5050169826 @default.
• W2917369987 creator A5056288840 @default.
• W2917369987 creator A5056927869 @default.
• W2917369987 creator A5066202291 @default.
• W2917369987 creator A5073160805 @default.
• W2917369987 creator A5075641592 @default.
• W2917369987 creator A5091765478 @default.
• W2917369987 date "2019-02-20" @default.
• W2917369987 modified "2023-10-17" @default.
• W2917369987 title "Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes" @default.
• W2917369987 cites W1971153622 @default.
• W2917369987 cites W2040422854 @default.
• W2917369987 cites W2071107715 @default.
• W2917369987 cites W2082001997 @default.
• W2917369987 cites W2088493848 @default.
• W2917369987 cites W2098419906 @default.
• W2917369987 cites W2116516363 @default.
• W2917369987 cites W2125730302 @default.
• W2917369987 cites W2141894953 @default.
• W2917369987 cites W2145025407 @default.
• W2917369987 cites W2149632928 @default.
• W2917369987 cites W2152000585 @default.
• W2917369987 cites W2153653258 @default.
• W2917369987 cites W2325843359 @default.
• W2917369987 cites W2587850379 @default.
• W2917369987 cites W2609075891 @default.
• W2917369987 cites W2672945187 @default.
• W2917369987 cites W2797607167 @default.
• W2917369987 cites W2903506831 @default.
• W2917369987 cites W4255565464 @default.
• W2917369987 doi "https://doi.org/10.1038/s41467-019-08852-4" @default.
• W2917369987 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6382754" @default.
• W2917369987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30787295" @default.
• W2917369987 hasPublicationYear "2019" @default.
• W2917369987 type Work @default.
• W2917369987 sameAs 2917369987 @default.
• W2917369987 citedByCount "119" @default.
• W2917369987 countsByYear W29173699872019 @default.
• W2917369987 countsByYear W29173699872020 @default.
• W2917369987 countsByYear W29173699872021 @default.
• W2917369987 countsByYear W29173699872022 @default.
• W2917369987 countsByYear W29173699872023 @default.
• W2917369987 crossrefType "journal-article" @default.
• W2917369987 hasAuthorship W2917369987A5012722902 @default.
• W2917369987 hasAuthorship W2917369987A5024667775 @default.
• W2917369987 hasAuthorship W2917369987A5029540294 @default.
• W2917369987 hasAuthorship W2917369987A5031918109 @default.
• W2917369987 hasAuthorship W2917369987A5036204802 @default.
• W2917369987 hasAuthorship W2917369987A5037085522 @default.
• W2917369987 hasAuthorship W2917369987A5037371315 @default.
• W2917369987 hasAuthorship W2917369987A5039027696 @default.
• W2917369987 hasAuthorship W2917369987A5050169826 @default.
• W2917369987 hasAuthorship W2917369987A5056288840 @default.
• W2917369987 hasAuthorship W2917369987A5056927869 @default.
• W2917369987 hasAuthorship W2917369987A5066202291 @default.
• W2917369987 hasAuthorship W2917369987A5073160805 @default.
• W2917369987 hasAuthorship W2917369987A5075641592 @default.
• W2917369987 hasAuthorship W2917369987A5091765478 @default.
• W2917369987 hasBestOaLocation W29173699871 @default.
• W2917369987 hasConcept C104317684 @default.
• W2917369987 hasConcept C105580179 @default.
• W2917369987 hasConcept C126322002 @default.
• W2917369987 hasConcept C142724271 @default.
• W2917369987 hasConcept C146957229 @default.
• W2917369987 hasConcept C167734588 @default.
• W2917369987 hasConcept C203014093 @default.
• W2917369987 hasConcept C2777025900 @default.
• W2917369987 hasConcept C2777397205 @default.
• W2917369987 hasConcept C2778937273 @default.
• W2917369987 hasConcept C2780394083 @default.
• W2917369987 hasConcept C2781188250 @default.
• W2917369987 hasConcept C50156730 @default.
• W2917369987 hasConcept C529278444 @default.
• W2917369987 hasConcept C55493867 @default.
• W2917369987 hasConcept C71924100 @default.
• W2917369987 hasConcept C86803240 @default.
• W2917369987 hasConcept C98274493 @default.
• W2917369987 hasConceptScore W2917369987C104317684 @default.
• W2917369987 hasConceptScore W2917369987C105580179 @default.
• W2917369987 hasConceptScore W2917369987C126322002 @default.
• W2917369987 hasConceptScore W2917369987C142724271 @default.
• W2917369987 hasConceptScore W2917369987C146957229 @default.
• W2917369987 hasConceptScore W2917369987C167734588 @default.
• W2917369987 hasConceptScore W2917369987C203014093 @default.
• W2917369987 hasConceptScore W2917369987C2777025900 @default.
• W2917369987 hasConceptScore W2917369987C2777397205 @default.
• W2917369987 hasConceptScore W2917369987C2778937273 @default.
• W2917369987 hasConceptScore W2917369987C2780394083 @default.
• W2917369987 hasConceptScore W2917369987C2781188250 @default.
• W2917369987 hasConceptScore W2917369987C50156730 @default.

• next