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- W2917383987 abstract "Abstract The concept and definitions of minimum therapeutic effective dose (MTED) and therapeutic window of a drug are presented. Design and analysis for estimating MTED are overviewed. Design issues such as inclusion of a placebo concurrent control, selection of dose levels, and sample size determination are addressed. Statistical analyses such as the application of analysis of variance and model‐based approach to estimating MTED are summarized. Discussion on internal validity vs. external evidence is also provided." @default.
- W2917383987 created "2019-03-02" @default.
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- W2917383987 date "2005-02-15" @default.
- W2917383987 modified "2023-10-03" @default.
- W2917383987 title "Minimum Therapeutically Effective Dose" @default.
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- W2917383987 doi "https://doi.org/10.1002/0470011815.b2a06018" @default.
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