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- W2917390930 endingPage "159" @default.
- W2917390930 startingPage "142" @default.
- W2917390930 abstract "Infections by the pathogenic yeasts Candida albicans and Candida glabrata are among the most common fungal diseases. The success of these species as human pathogens is contingent on their ability to resist antifungal therapy and thrive within the human host. C. glabrata is especially resilient to azole antifungal treatment, while C. albicans is best known for its wide array of virulence features. The core mechanisms that underlie antifungal resistance and virulence in these pathogens has been continuously addressed, but the investigation on how such mechanisms evolve according to each environment is scarcer. This review aims to explore current knowledge on micro-evolution experiments to several treatment and host-associated conditions in C. albicans and C. glabrata. The analysis of adaptation strategies that evolve over time will allow to better understand the mechanisms by which Candida species are able to achieve stable phenotypes in real-life scenarios, which are the ones that should constitute the most interesting drug targets." @default.
- W2917390930 created "2019-03-02" @default.
- W2917390930 creator A5004874754 @default.
- W2917390930 creator A5046370719 @default.
- W2917390930 creator A5058929083 @default.
- W2917390930 creator A5059367257 @default.
- W2917390930 creator A5072690759 @default.
- W2917390930 creator A5081964234 @default.
- W2917390930 date "2019-03-04" @default.
- W2917390930 modified "2023-09-30" @default.
- W2917390930 title "Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection" @default.
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