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- W2917404844 abstract "Abstract Objective To verify whether there are differences between populations of CD8 + and FoxP3 + T cells in lesions of oral lichen planus associated with hepatitis C virus chronic infection (OLP‐HCV) and lesions of idiopathic oral lichen planus (OLP‐I). Materials and Methods A case–control study was performed using a convenience sample of 11 paraffin‐embedded tissue blocks of OLP‐HCV and 19 of OLP‐I. Histological sections stained with haematoxylin and eosin were used to classify the intensity of inflammatory infiltrate. Immunohistochemistry was used to identify CD8 + and FoxP3 + T cells. The count of positive cells was compared between the two groups and correlated to clinical and demographic data ( p < 0.05). Results There were no statistically significant differences in the distribution of CD8 + and FoxP3 + T cells regarding the inflammatory infiltrate in lesions of OLP‐HCV and OLP‐I. Atrophic/erosive lesions showed a higher relationship between counts of CD8/FoxP3 T cells per mm 2 ( p = 0.018) and counts of CD8 + T cells per mm 2 ( p = 0.034) in OLP‐HCV group compared to OLP‐I group. Conclusion Overall, no difference was found between cell populations in the lesions of OLP‐HCV and OLP‐I. However, atrophic/erosive lesions of OLP‐HCV had a higher amount of CD8 + T cells and lower FoxP3 expression." @default.
- W2917404844 created "2019-03-02" @default.
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- W2917404844 date "2019-03-15" @default.
- W2917404844 modified "2023-10-17" @default.
- W2917404844 title "Subset of CD8+ and FOXP3 + T cells in lichen planus associated with chronic hepatitis C infection" @default.
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- W2917404844 doi "https://doi.org/10.1111/odi.13069" @default.
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