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- W2917479871 abstract "Prenatal exposure to mercury (Hg) is associated with adverse neurobehavioral outcomes in children. As Hg can interfere with normal placental functioning, as well as cross the placenta and target the fetal brain, prenatal Hg exposure can negatively impact fetal growth and development both directly and indirectly. To examine potential associations between placental DNA methylation changes, infant toenail Hg, and neurobehavioral outcomes, we profiled the DNA methylation status in 192 placental samples using the Illumina Infinium HumanMethylation450K array platform. Hg data were analyzed in toenail clipping samples from a subset of 41 of these 192 infants, and neurobehavior was assessed using the NICU Network Neurobehavioral Scales (NNNS) in an independent subset of 151 of these infants. A significant association was found to exist between placental methylation, epigenome-wide, and infant toenail Hg tertile, with an omnibus p- value of 0.017. We identified 339 CpG loci with differential methylation methylation between toenail Hg tertiles. These 339 CpG loci were subsequently found to be associated with a high-risk neurodevelopmental profile (omnibus p-value=0.007) based on newborn assessments using the NNNS. 10 of these CpG loci had p<0.01 for the association with high-risk NNNS profile, and 6 of these 10 CpG loci reside in the EMID2 gene and were hypomethylated in the placental tissue of high-risk profile infants compared to non-high risk profile infants. The observed hypomethylation at these EMID2 CpG loci may represent a novel mechanism linking in utero Hg exposure and adverse infant neurobehavioral outcomes." @default.
- W2917479871 created "2019-03-02" @default.
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- W2917479871 date "2014-10-20" @default.
- W2917479871 modified "2023-09-28" @default.
- W2917479871 title "Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes" @default.
- W2917479871 doi "https://doi.org/10.1289/isee.2014.o-148" @default.
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