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- W2917502405 abstract "To provide an overview of recent pharmacological treatments for portal hypertension evaluated in early clinical trials, with particular emphasis on the pathophysiological basis of their use.In patients with compensated cirrhosis, even small decreases in portal pressure (as small as 1 mmHg) are associated with a lower probability of decompensation. In patients with decompensated cirrhosis, portal pressure response to non-selective beta-blocker (NSBB) therapy is associated with a lower mortality. When present, significant portal hypertension persists even after elimination of the etiology of cirrhosis and this justifies the continued development of new drugs that target portal hypertension.Over several decades we have gained great depth in the understanding of portal hypertension, its mechanisms and complications. NSBBs, which act by reducing portal venous inflow (an extrahepatic target), are effective in reducing portal pressure and have been the mainstay of therapy for portal hypertension in the last 35 years -being effective in preventing decompensation and variceal hemorrhage. However, because not all patients will have a sufficient response to NSBB and some may be intolerant to NSBB, alternative drugs or drugs that will augment the effect of NSBB on portal pressure are being tested in pre-clinical and early-clinical trials. Many of these drugs target more than one of the intrahepatic or extrahepatic mechanisms implicated in the pathogenesis of portal hypertension in cirrhosis. Out of these proposed therapies, statins have emerged as the most promising new pharmacological therapy for the treatment of portal hypertension." @default.
- W2917502405 created "2019-03-02" @default.
- W2917502405 creator A5018974631 @default.
- W2917502405 creator A5063217682 @default.
- W2917502405 date "2019-02-19" @default.
- W2917502405 modified "2023-10-18" @default.
- W2917502405 title "Future Pharmacological Therapies of Portal Hypertension" @default.
- W2917502405 cites W1523152575 @default.
- W2917502405 cites W1806216053 @default.
- W2917502405 cites W1829489326 @default.
- W2917502405 cites W1896059571 @default.
- W2917502405 cites W1963828794 @default.
- W2917502405 cites W1964051982 @default.
- W2917502405 cites W1965709993 @default.
- W2917502405 cites W1968641413 @default.
- W2917502405 cites W1970740746 @default.
- W2917502405 cites W1977983569 @default.
- W2917502405 cites W1982878947 @default.
- W2917502405 cites W1984074063 @default.
- W2917502405 cites W1986577643 @default.
- W2917502405 cites W1993340951 @default.
- W2917502405 cites W1993383522 @default.
- W2917502405 cites W1997037000 @default.
- W2917502405 cites W1997485766 @default.
- W2917502405 cites W1999133483 @default.
- W2917502405 cites W2001137775 @default.
- W2917502405 cites W2004972926 @default.
- W2917502405 cites W2007069606 @default.
- W2917502405 cites W2011052019 @default.
- W2917502405 cites W2014616693 @default.
- W2917502405 cites W2016751268 @default.
- W2917502405 cites W2025077770 @default.
- W2917502405 cites W2028825909 @default.
- W2917502405 cites W2032864171 @default.
- W2917502405 cites W2033260776 @default.
- W2917502405 cites W2033338195 @default.
- W2917502405 cites W2035166345 @default.
- W2917502405 cites W2037788436 @default.
- W2917502405 cites W2038347135 @default.
- W2917502405 cites W2041553454 @default.
- W2917502405 cites W2061548760 @default.
- W2917502405 cites W2061794123 @default.
- W2917502405 cites W2066273470 @default.
- W2917502405 cites W2066867615 @default.
- W2917502405 cites W2072743531 @default.
- W2917502405 cites W2072755195 @default.
- W2917502405 cites W2076642394 @default.
- W2917502405 cites W2077820981 @default.
- W2917502405 cites W2080308468 @default.
- W2917502405 cites W2080475565 @default.
- W2917502405 cites W2082027499 @default.
- W2917502405 cites W2086711192 @default.
- W2917502405 cites W2090738619 @default.
- W2917502405 cites W2095412079 @default.
- W2917502405 cites W2099295251 @default.
- W2917502405 cites W2101099470 @default.
- W2917502405 cites W2101512090 @default.
- W2917502405 cites W2104193042 @default.
- W2917502405 cites W2112665890 @default.
- W2917502405 cites W2118330575 @default.
- W2917502405 cites W2118981005 @default.
- W2917502405 cites W2124773480 @default.
- W2917502405 cites W2126903895 @default.
- W2917502405 cites W2133662506 @default.
- W2917502405 cites W2136578956 @default.
- W2917502405 cites W2140119280 @default.
- W2917502405 cites W2144913800 @default.
- W2917502405 cites W2146040830 @default.
- W2917502405 cites W2149727669 @default.
- W2917502405 cites W2156651128 @default.
- W2917502405 cites W2158501924 @default.
- W2917502405 cites W2159845343 @default.
- W2917502405 cites W2160155876 @default.
- W2917502405 cites W2162226128 @default.
- W2917502405 cites W2166360182 @default.
- W2917502405 cites W2166467296 @default.
- W2917502405 cites W2171925512 @default.
- W2917502405 cites W2181185500 @default.
- W2917502405 cites W2190431594 @default.
- W2917502405 cites W2234170759 @default.
- W2917502405 cites W2308667797 @default.
- W2917502405 cites W2322796276 @default.
- W2917502405 cites W2328023807 @default.
- W2917502405 cites W2406748516 @default.
- W2917502405 cites W2433798275 @default.
- W2917502405 cites W2505883712 @default.
- W2917502405 cites W2521619896 @default.
- W2917502405 cites W2533741811 @default.
- W2917502405 cites W2546046192 @default.
- W2917502405 cites W2555707002 @default.
- W2917502405 cites W2572288254 @default.
- W2917502405 cites W2593663511 @default.
- W2917502405 cites W2612531212 @default.
- W2917502405 cites W2612584389 @default.
- W2917502405 cites W2613180696 @default.
- W2917502405 cites W2617999145 @default.
- W2917502405 cites W2736841222 @default.
- W2917502405 cites W2753051611 @default.