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- W2917506380 abstract "Abstract The inferior colliculus (IC) receives and integrates excitatory and inhibitory inputs from many bilateral lower auditory nuclei, intrinsic projections within IC, contralateral IC through the commissure of IC and from the auditory cortex (AC). These excitatory and inhibitory inputs from both ascending and descending auditory pathways contribute significantly to auditory response properties and temporal signal processing in IC. The present study examines the contribution of gamma-aminobutyric acid-ergic (GABAergic) inhibition of dorsal nucleus of the lateral lemniscus (DNLL) in influencing the response properties and amplitude sensitivity of contralateral IC neurons using focal electrical stimulation of contralateral DNLL and by the application of bicuculline to the recording site of modulated IC neurons. Focal electrical stimulation of contralateral DNLL produces inhibition (78.1%), facilitation (7.1%) or no effect (14.8%) in the number of spikes, firing duration and the first-spike latency of modulated IC neurons. The degree of modulation is inversely correlated to the difference in best frequency (BF) between electrically stimulated DNLL neurons and modulated IC neurons (p" @default.
- W2917506380 created "2019-03-02" @default.
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- W2917506380 date "2019-06-01" @default.
- W2917506380 modified "2023-09-25" @default.
- W2917506380 title "Focal electrical stimulation of dorsal nucleus of the lateral lemniscus modulates auditory response properties of inferior collicular neurons in the albino mouse" @default.
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- W2917506380 doi "https://doi.org/10.1016/j.heares.2019.01.024" @default.
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