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• W2917532056 endingPage "e10744" @default.
• W2917532056 startingPage "e10744" @default.
• W2917532056 abstract "Background: The increasing prevalence of Alzheimer disease (AD) emphasizes the need for effective treatments. Both pharmacological therapies such as nutrition therapy (NT) and nonpharmacologic therapies including traditional treatment or personalized treatment (e.g., physical exercise, music therapy, computerized cognitive training) have been approved for the treatment of AD or mild cognitive impairment (MCI) in numerous areas. Methods: The aim of this study was to compare 4 types of interventions, physical exercise (PE), music therapy (MT), computerized cognitive training (CCT), and NT, in older adults with mild to moderate AD or MCI and identify the most effective intervention for their cognitive function. We used a system of search strategies to identify relevant studies and include randomized controlled trials (RCTs), placebo-controlled trials evaluating the efficacy and safety of 4 interventions in patients with AD or MCI. We updated the relevant studies which were published before March 2017 as a full-text article. Using Bayesian network meta-analysis (NMA), we ranked cognitive ability based objectively on Mini-Mental State Examination (MMSE), and assessed neuropsychiatric symptoms based on Neuropsychiatric Inventory (NPI). Pairwise and network meta-analyses were sequentially performed for efficacy and safety of intervention compared to control group through RCTs included. Results: We included 17 RCTs. Fifteen trials (n = 1747) were pooled for cognition and no obvious heterogeneity was found (I2 = 21.7%, P = .212) in NMA, the mean difference (MD) of PE (MD = 2.1, confidence interval [CI]: 0.44–3.8) revealed that PE was significantly efficacious in the treatment group in terms of MMSE. Five trials (n = 660) assessed neuropsychiatric symptoms with an obvious heterogeneity (I2 = 61.6%, P = .034), the MD of CCT (MD = −7.7, CI: −14 to −2.4), revealing that CCT was significantly efficacious in NPI. Conclusions: As the first NMA comparing different interventions for AD and MCI, our study suggests that PE and CCT might have a significant improvement in cognition and neuropsychiatric symptoms respectively. Moreover, nonpharmacological therapies might be better than pharmacological therapies." @default.
• W2917532056 created "2019-03-02" @default.
• W2917532056 creator A5016608679 @default.
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• W2917532056 date "2018-05-01" @default.
• W2917532056 modified "2023-10-03" @default.
• W2917532056 title "Comparison of multiple interventions for older adults with Alzheimer disease or mild cognitive impairment" @default.
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• W2917532056 cites W1842042459 @default.
• W2917532056 cites W1867964229 @default.
• W2917532056 cites W190432982 @default.
• W2917532056 cites W1905660693 @default.
• W2917532056 cites W1965529356 @default.
• W2917532056 cites W1967385770 @default.
• W2917532056 cites W1967544439 @default.
• W2917532056 cites W1977733636 @default.
• W2917532056 cites W1978372802 @default.
• W2917532056 cites W1991189029 @default.
• W2917532056 cites W1992447918 @default.
• W2917532056 cites W1999538109 @default.
• W2917532056 cites W2002040053 @default.
• W2917532056 cites W2004474087 @default.
• W2917532056 cites W2009253656 @default.
• W2917532056 cites W2010699829 @default.
• W2917532056 cites W2010860427 @default.
• W2917532056 cites W2012179098 @default.
• W2917532056 cites W2014274399 @default.
• W2917532056 cites W2024737544 @default.
• W2917532056 cites W2040557955 @default.
• W2917532056 cites W2042726745 @default.
• W2917532056 cites W2046393612 @default.
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• W2917532056 cites W2047680862 @default.
• W2917532056 cites W2056270695 @default.
• W2917532056 cites W2056271161 @default.
• W2917532056 cites W2060801523 @default.
• W2917532056 cites W2064618467 @default.
• W2917532056 cites W2070148953 @default.
• W2917532056 cites W2070558791 @default.
• W2917532056 cites W2071254369 @default.
• W2917532056 cites W2072572422 @default.
• W2917532056 cites W2083674804 @default.
• W2917532056 cites W2085252187 @default.
• W2917532056 cites W2086716919 @default.
• W2917532056 cites W2092674727 @default.
• W2917532056 cites W2093438876 @default.
• W2917532056 cites W2103404050 @default.
• W2917532056 cites W2105669432 @default.
• W2917532056 cites W2105680641 @default.
• W2917532056 cites W2107820540 @default.
• W2917532056 cites W2113097158 @default.
• W2917532056 cites W2113144077 @default.
• W2917532056 cites W2126930838 @default.
• W2917532056 cites W2129821518 @default.
• W2917532056 cites W2131722081 @default.
• W2917532056 cites W2140699272 @default.
• W2917532056 cites W2149116902 @default.
• W2917532056 cites W2156098321 @default.
• W2917532056 cites W2158499098 @default.
• W2917532056 cites W2165136235 @default.
• W2917532056 cites W2177634114 @default.
• W2917532056 cites W2210351761 @default.
• W2917532056 cites W2238321864 @default.
• W2917532056 cites W2250336819 @default.
• W2917532056 cites W2326899406 @default.
• W2917532056 cites W2553827870 @default.
• W2917532056 cites W2571668088 @default.
• W2917532056 cites W2577650921 @default.
• W2917532056 cites W2580517642 @default.
• W2917532056 cites W2582524520 @default.
• W2917532056 cites W2606046023 @default.
• W2917532056 cites W2991792334 @default.
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• W2917532056 doi "https://doi.org/10.1097/md.0000000000010744" @default.
• W2917532056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5976284" @default.
• W2917532056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29768349" @default.
• W2917532056 hasPublicationYear "2018" @default.
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