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• W2917590165 startingPage "1127" @default.
• W2917590165 abstract "Chloramphenicol nitroreductase (CNR), a drug-modifying enzyme from Haemophilus influenzae, has been shown to be responsible for the conversion of the nitro group into an amine in the antibiotic chloramphenicol (CAM). Since CAM structurally bears a 4-nitrobenzene moiety, we explored the substrate promiscuity of CNR by investigating its nitroreduction of 4-nitrobenzyl derivatives. We tested twenty compounds containing a nitrobenzene core, two nitropyridines, one compound with a vinylogous nitro group, and two aliphatic nitro compounds. In addition, we also synthesized twenty-eight 4-nitrobenzyl derivatives with ether, ester, and thioether substituents and assessed the relative activity of CNR in their presence. We found several of these compounds to be modified by CNR, with the enzyme activity ranging from 1 to 150% when compared to CAM. This data provides insights into two areas: (i) chemoenzymatic reduction of select compounds to avoid harsh chemicals and heavy metals routinely used in reductions of nitro groups and (ii) functional groups that would aid CAM in overcoming the activity of this enzyme." @default.
• W2917590165 created "2019-03-02" @default.
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• W2917590165 date "2019-05-01" @default.
• W2917590165 modified "2023-09-26" @default.
• W2917590165 title "Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives" @default.
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• W2917590165 doi "https://doi.org/10.1016/j.bmcl.2019.02.025" @default.
• W2917590165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6431269" @default.
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• W2917590165 hasPublicationYear "2019" @default.
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