FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917608416> ?p ?o ?g. }

• W2917608416 endingPage "S280" @default.
• W2917608416 startingPage "S280.1" @default.
• W2917608416 abstract "<h3></h3> Acute renal failure (ARF) in the pediatric intensive care unit (PICU) is associated with significant morbidity, with mortality greater than 50%, despite advances in dialytic therapies. While use of continuous renal replacement therapy (CRRT) has become widespread in the pediatric population, there are few published data regarding outcomes for these critically ill children. The purpose of this study was to describe our experience with CRRT over the past 5 years in the PICU. We looked at the association of several factors with survival in a retrospective analysis of 76 children with ARF admitted to our institution between 1/2000 and 9/2005. The primary outcome was survival to discharge; secondary outcomes were duration of mechanical ventilation, PICU stay, hospitalization, and time to renal recovery. The median age of the patients was 69 months (range 0.10 to 227), median PRISM II score was 14 (range 0 to 39), median BUN at CRRT initiation was 51.5 mg/dL (range 2 to 220), median creatinine at CRRT initiation was 2.4 mg/dL (range 0.2 to 7.8). Of the 76 patients, 63.2% had multiple organ dysfunction syndrome (MODS, defined as $ 3 organs) as the primary cause of renal failure, 22.4% were oncology patients, and 15.8% were bone marrow transplant patients. Overall PICU survival was 55.3%, similar to that previously described. Several factors were significantly different between those who survived to PICU discharge and those who died. Presence of fluid overload was the stated reason for CRRT initiation 62% of the time in survivors versus 91% of time in non-survivors (p < .01). Median mean airway pressure 24 hours after CRRT initiation was 13 cmH2O in survivors versus 17.5 cmH20 in non-survivors (p = .038). Median percent fluid overload at time of CRRT initiation was 7.3 in survivors versus 22.3 in non-survivors (p < .001). All non-survivors had MODS; only 26% of survivors had MODS (p < .001). Dose of dialysis did not differ between the two groups of patients. For survivors there was a significant linear relationship between percent fluid overload and time to renal recovery (r² = .30, p = .01). Percent fluid overload was also associated with significantly prolonged days of mechanical ventilation (r² = .18, p = .01), days spent in the PICU (r² = .23, p = .01), and duration of hospitalization (r² = .28, p = .01). We conclude that in patients with ARF who require CRRT, the presence of MODS and fluid overload greater than 20% at the time of CRRT initiation are significantly associated with higher mortality. Additionally, we report the novel findings that duration of mechanical ventilation, PICU stay, hospitalization, and time to renal recovery were all significantly prolonged for patients who had fluid overload greater than 20%." @default.
• W2917608416 created "2019-03-02" @default.
• W2917608416 creator A5015066501 @default.
• W2917608416 creator A5058568676 @default.
• W2917608416 creator A5079124812 @default.
• W2917608416 date "2006-01-01" @default.
• W2917608416 modified "2023-09-27" @default.
• W2917608416 title "135 OUTCOMES OF CRITICALLY ILL CHILDREN REQUIRING CONTINUOUS RENAL REPLACEMENT THERAPY: A RETROSPECTIVE ANALYSIS." @default.
• W2917608416 doi "https://doi.org/10.2310/6650.2005.x0008.134" @default.
• W2917608416 hasPublicationYear "2006" @default.
• W2917608416 type Work @default.
• W2917608416 sameAs 2917608416 @default.
• W2917608416 citedByCount "0" @default.
• W2917608416 crossrefType "journal-article" @default.
• W2917608416 hasAuthorship W2917608416A5015066501 @default.
• W2917608416 hasAuthorship W2917608416A5058568676 @default.
• W2917608416 hasAuthorship W2917608416A5079124812 @default.
• W2917608416 hasConcept C126322002 @default.
• W2917608416 hasConcept C167135981 @default.
• W2917608416 hasConcept C177713679 @default.
• W2917608416 hasConcept C187212893 @default.
• W2917608416 hasConcept C2776376669 @default.
• W2917608416 hasConcept C2777080012 @default.
• W2917608416 hasConcept C2778939556 @default.
• W2917608416 hasConcept C2779541074 @default.
• W2917608416 hasConcept C2780472472 @default.
• W2917608416 hasConcept C2908647359 @default.
• W2917608416 hasConcept C71924100 @default.
• W2917608416 hasConcept C99454951 @default.
• W2917608416 hasConceptScore W2917608416C126322002 @default.
• W2917608416 hasConceptScore W2917608416C167135981 @default.
• W2917608416 hasConceptScore W2917608416C177713679 @default.
• W2917608416 hasConceptScore W2917608416C187212893 @default.
• W2917608416 hasConceptScore W2917608416C2776376669 @default.
• W2917608416 hasConceptScore W2917608416C2777080012 @default.
• W2917608416 hasConceptScore W2917608416C2778939556 @default.
• W2917608416 hasConceptScore W2917608416C2779541074 @default.
• W2917608416 hasConceptScore W2917608416C2780472472 @default.
• W2917608416 hasConceptScore W2917608416C2908647359 @default.
• W2917608416 hasConceptScore W2917608416C71924100 @default.
• W2917608416 hasConceptScore W2917608416C99454951 @default.
• W2917608416 hasIssue "1" @default.
• W2917608416 hasLocation W29176084161 @default.
• W2917608416 hasOpenAccess W2917608416 @default.
• W2917608416 hasPrimaryLocation W29176084161 @default.
• W2917608416 hasRelatedWork W1561173786 @default.
• W2917608416 hasRelatedWork W2063317977 @default.
• W2917608416 hasRelatedWork W2140796490 @default.
• W2917608416 hasRelatedWork W2376567783 @default.
• W2917608416 hasRelatedWork W2906352413 @default.
• W2917608416 hasRelatedWork W2969844749 @default.
• W2917608416 hasRelatedWork W3037353703 @default.
• W2917608416 hasRelatedWork W3194544638 @default.
• W2917608416 hasRelatedWork W4212792695 @default.
• W2917608416 hasRelatedWork W4289656489 @default.
• W2917608416 hasVolume "54" @default.
• W2917608416 isParatext "false" @default.
• W2917608416 isRetracted "false" @default.
• W2917608416 magId "2917608416" @default.
• W2917608416 workType "article" @default.