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- W2917676499 abstract "Significance Multiple myeloma is a deadly disease for which new therapies are urgently needed. B cell maturation antigen (BCMA) is an excellent target for therapy of myeloma because it is a lineage restricted differentiation protein that is expressed on myeloma cells and plasma cells but not on essential organs. We have produced recombinant immunotoxins that target and kill myeloma cells expressing BCMA. We have examined two mouse models of myeloma and show that the anti-BCMA immunotoxins produce long-term complete regressions in both models. These data support further preclinical development of these agents." @default.
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- W2917676499 date "2019-02-19" @default.
- W2917676499 modified "2023-10-16" @default.
- W2917676499 title "Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models" @default.
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- W2917676499 doi "https://doi.org/10.1073/pnas.1821733116" @default.
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