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• W2917754900 abstract "Cellular therapy of the corneal stroma with either ocular or extraocular stem cells has been gaining a lot of interest along the last decade, while multiple publications from different research groups are showing its potential benefits in relation with their capacity to improve or alleviate corneal scars, improve corneal transparency in metabolic diseases by enhancing the catabolism of the accumulated molecules, generate new organized collagen within the host stroma and present immunosuppressive and immunomodulatory properties. Extraocular stem cells have a potential better autologous application as they don’t require a healthy contralateral eye and they don’t involve any ophthalmic procedure for their isolation, so it is usually better accepted by a patient who already presents a corneal disease. Among them, mesenchymal stem cells have been the most widely assayed and the ones with better potential to differentiate into functional adult keratocytes in vivo and in vitro. While embryonic stem cells have been partially abandoned due to their ethical implications, the discovery of the induced pluripotent stem cells (iPSCs) has opened a new and very promising field for future research as they are pluripotent cells with the capacity to theoretically differentiate into any cell line, but they derive from adult differentiated cells, avoiding the limitations that embryonic cells present on this regard." @default.
• W2917754900 created "2019-03-02" @default.
• W2917754900 creator A5043568424 @default.
• W2917754900 date "2019-01-01" @default.
• W2917754900 modified "2023-09-24" @default.
• W2917754900 title "Cell Therapy of the Corneal Stroma Using Ex Vivo Cultured Extraocular Cells" @default.
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• W2917754900 doi "https://doi.org/10.1007/978-3-030-01304-2_26" @default.
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