FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2917771007> ?p ?o ?g. }

• W2917771007 endingPage "455" @default.
• W2917771007 startingPage "448" @default.
• W2917771007 abstract "Stem cell aging underlies aging-associated disorders, such as steeply increased incidences of tumors and impaired regeneration capacity upon stress. However, whether and how the intestinal stem cells age remains largely unknown. Here we show that intestinal stem cells derived from 24-month-old mice hardly form typical organoids with crypt-villus structures, but rather mainly form big, rounded cysts devoid of differentiated cell types, which mimics the culturing of heterozygous APC-deficient cells from the APCmin mouse line. Further analysis showed that cultured crypts derived from aged mice exhibited reduced expression levels of differentiation genes and higher expression of Wnt target genes. Lowering the concentration of R-spondin-1 in the culture system significantly reduced formation of rounded cysts, accompanied by an increased formation of organoids from crypts derived from old mice. We are the first to uncover that intestinal stem cells derived from old mice harbor significant deficiency in differentiation that can be partially rescued through a reduction in R-spondin-1 exposure. This could be highly relevant to intestinal tumor development and the reduced regeneration potential observed in the aged population. Our study provides the first experimental evidence that an over-responsiveness to Wnt/beta-catenin signaling of aged intestinal stem cells mediates the aging-induced deficiency in differentiation, and could serve as a potential target to ameliorate aging-associated intestinal pathologies." @default.
• W2917771007 created "2019-03-02" @default.
• W2917771007 creator A5012483042 @default.
• W2917771007 creator A5020769177 @default.
• W2917771007 creator A5030561241 @default.
• W2917771007 creator A5034525726 @default.
• W2917771007 creator A5045663774 @default.
• W2917771007 creator A5053245239 @default.
• W2917771007 creator A5070487287 @default.
• W2917771007 creator A5077390725 @default.
• W2917771007 date "2019-02-21" @default.
• W2917771007 modified "2023-10-03" @default.
• W2917771007 title "Wnt Signaling Mediates the Aging-Induced Differentiation Impairment of Intestinal Stem Cells" @default.
• W2917771007 cites W1872124954 @default.
• W2917771007 cites W1965157206 @default.
• W2917771007 cites W1982603620 @default.
• W2917771007 cites W1984365472 @default.
• W2917771007 cites W1987582055 @default.
• W2917771007 cites W2018348035 @default.
• W2917771007 cites W2029556699 @default.
• W2917771007 cites W2038714514 @default.
• W2917771007 cites W2066362124 @default.
• W2917771007 cites W2084881895 @default.
• W2917771007 cites W2087500600 @default.
• W2917771007 cites W2090562908 @default.
• W2917771007 cites W2092642151 @default.
• W2917771007 cites W2112763851 @default.
• W2917771007 cites W2122520505 @default.
• W2917771007 cites W2124153237 @default.
• W2917771007 cites W2133899877 @default.
• W2917771007 cites W2150719976 @default.
• W2917771007 cites W2151928111 @default.
• W2917771007 cites W2155978263 @default.
• W2917771007 cites W2157010562 @default.
• W2917771007 cites W2157910818 @default.
• W2917771007 cites W2158115943 @default.
• W2917771007 cites W2162756888 @default.
• W2917771007 cites W2165087323 @default.
• W2917771007 cites W2171794152 @default.
• W2917771007 cites W2171977041 @default.
• W2917771007 cites W2171996338 @default.
• W2917771007 cites W2261147410 @default.
• W2917771007 cites W2509722695 @default.
• W2917771007 cites W2594543006 @default.
• W2917771007 cites W2596902967 @default.
• W2917771007 cites W2735626641 @default.
• W2917771007 cites W2769478432 @default.
• W2917771007 cites W2884297297 @default.
• W2917771007 cites W2886230392 @default.
• W2917771007 doi "https://doi.org/10.1007/s12015-019-09880-9" @default.
• W2917771007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6534527" @default.
• W2917771007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30790135" @default.
• W2917771007 hasPublicationYear "2019" @default.
• W2917771007 type Work @default.
• W2917771007 sameAs 2917771007 @default.
• W2917771007 citedByCount "33" @default.
• W2917771007 countsByYear W29177710072019 @default.
• W2917771007 countsByYear W29177710072020 @default.
• W2917771007 countsByYear W29177710072021 @default.
• W2917771007 countsByYear W29177710072022 @default.
• W2917771007 countsByYear W29177710072023 @default.
• W2917771007 crossrefType "journal-article" @default.
• W2917771007 hasAuthorship W2917771007A5012483042 @default.
• W2917771007 hasAuthorship W2917771007A5020769177 @default.
• W2917771007 hasAuthorship W2917771007A5030561241 @default.
• W2917771007 hasAuthorship W2917771007A5034525726 @default.
• W2917771007 hasAuthorship W2917771007A5045663774 @default.
• W2917771007 hasAuthorship W2917771007A5053245239 @default.
• W2917771007 hasAuthorship W2917771007A5070487287 @default.
• W2917771007 hasAuthorship W2917771007A5077390725 @default.
• W2917771007 hasBestOaLocation W29177710071 @default.
• W2917771007 hasConcept C104317684 @default.
• W2917771007 hasConcept C134018914 @default.
• W2917771007 hasConcept C137620995 @default.
• W2917771007 hasConcept C148738053 @default.
• W2917771007 hasConcept C171056886 @default.
• W2917771007 hasConcept C203014093 @default.
• W2917771007 hasConcept C20875687 @default.
• W2917771007 hasConcept C2781077229 @default.
• W2917771007 hasConcept C28328180 @default.
• W2917771007 hasConcept C31695470 @default.
• W2917771007 hasConcept C502942594 @default.
• W2917771007 hasConcept C529295009 @default.
• W2917771007 hasConcept C54355233 @default.
• W2917771007 hasConcept C62478195 @default.
• W2917771007 hasConcept C66090201 @default.
• W2917771007 hasConcept C86803240 @default.
• W2917771007 hasConcept C95444343 @default.
• W2917771007 hasConceptScore W2917771007C104317684 @default.
• W2917771007 hasConceptScore W2917771007C134018914 @default.
• W2917771007 hasConceptScore W2917771007C137620995 @default.
• W2917771007 hasConceptScore W2917771007C148738053 @default.
• W2917771007 hasConceptScore W2917771007C171056886 @default.
• W2917771007 hasConceptScore W2917771007C203014093 @default.
• W2917771007 hasConceptScore W2917771007C20875687 @default.
• W2917771007 hasConceptScore W2917771007C2781077229 @default.
• W2917771007 hasConceptScore W2917771007C28328180 @default.
• W2917771007 hasConceptScore W2917771007C31695470 @default.

• next