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- W2917771774 abstract "Abstract The development of multifunctional drug delivery systems (DDSs) capable of carrying various drugs for diverse disease treatments is highly desirable yet remains challenging. Taking advantage of the excellent properties of silicon‐containing nanodots (SiNDs), a self‐traceable nanogel‐based DDS formed by the co‐assembly of a “soft” copolymer and a “hard” fluorescent SiND is developed, which has tunable size/fluorescence, high encapsulation efficiencies (60–92%) for various small molecule drugs, and pH‐responsive drug release capability. As a proof of concept, 5‐aminolevulinic acid, a hydrophilic prodrug of protoporphyrin IX (PpIX), and tirapazamine (TPZ), a water‐soluble hypoxia‐responsive drug, are successfully and stably encapsulated into the nanogels. The drug‐loaded green‐emissive nanogels achieve the selective biosynthesis of red‐fluorescent PpIX in tumors and can serve as a ratiometric probe for accurate cancer diagnosis. Moreover, the in situ synthesized PpIX can consume oxygen to produce toxic singlet oxygen in the tumor microenvironment under light irradiation, thus activating the hypoxia‐dependent cytotoxicity of TPZ. Thanks to the less PpIX production and the neutral/normoxic environment in normal tissues, the nanoagents elicit negligible toxicity to normal cells even under light irradiation. Overall, this work develops a novel strategy for constructing a series of smart nanogels as universal DDSs and realizes precision cancer theranostics." @default.
- W2917771774 created "2019-03-02" @default.
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- W2917771774 date "2019-02-25" @default.
- W2917771774 modified "2023-09-30" @default.
- W2917771774 title "Supramolecular Nanogel‐Based Universal Drug Carriers Formed by “Soft–Hard” Co‐Assembly: Accurate Cancer Diagnosis and Hypoxia‐Activated Cancer Therapy" @default.
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- W2917771774 doi "https://doi.org/10.1002/adtp.201800140" @default.
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