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• W2917773405 startingPage "1138" @default.
• W2917773405 abstract "A series of artemisinin derivatives with MDR reversal activity were designed and synthesized. All hybrids were screened to anticancer activities against four human cancer cell lines (A549, MCF-7, HepG-2, MDA-MB-231) and normal human hepatic cell (L02) in vitro. Most of the new compounds showed higher anticancer activities than artemisinin, among which compounds 11a and 11c displayed superior potency with IC50 6.78 μM and 5.25 μM against MCF-7, respectively. The further research indicated that the most potent 11c induced cell cycle arrest at G2 phase in MCF-7. Additionally, compound 11c showed remarkable MDR reversal activity which reversed adriamycin against MCF-7/ADR cells with IC50 0.76 μM." @default.
• W2917773405 created "2019-03-02" @default.
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• W2917773405 date "2019-05-01" @default.
• W2917773405 modified "2023-10-16" @default.
• W2917773405 title "Artemisinin-indole and artemisinin-imidazole hybrids: Synthesis, cytotoxic evaluation and reversal effects on multidrug resistance in MCF-7/ADR cells" @default.
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• W2917773405 doi "https://doi.org/10.1016/j.bmcl.2019.02.021" @default.
• W2917773405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30837097" @default.
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